摘要
目的 :探讨乙型肝炎相关性肾炎经大剂量泼尼松治疗后患者肝组织学特点。方法 :采用HE、银浸Gomori染色及免疫组织化学染色方法观察了 16例乙型肝炎相关性肾炎患者使用大剂量泼尼松后 ,其肝组织病理变化和HBcAg、B7 1表达情况。结果 :16例患者肝组织炎性损害轻微 (G1,S0～S1) ,呈现大量毛玻璃样细胞 ,12例患者肝脂肪变 ,以大泡性为主。全部检测标本均呈HBcAg胞核强表达 ,仅 1例呈B7 1胞浆弱表达。 结论 :乙型肝炎相关性肾炎经大剂量泼尼松治疗后 ,肝组织炎性细胞浸润轻微 ,以肝细胞呈毛玻璃样变。
Objective: To observe the liver histologic characteristics of patients with HBV associated glomerulonephritis(HBV-GN) long time of Prednisone treatment.Methods:16 patients with HBV-GN treated with Prednisone were investiga- ted for characteristics of liver histopathology and expression of B7-1 and hepatitis B core antigen used HE stain,Gomori stain, and immunohistochemical assay separately.Results:16 cases had liver mild inflammation(G1, S0～S1), ground glass hepatocytes more commonly. Hepatic steatosis was found in 12 cases and macrovesicular steatosis was the main type. All the patients had highly expression of HBcAg mainly in nucleus. Only one had faintly B7-1 expression.Conclusion: Liver histologic characteristics of patients with HBV -GN treated with Prednisone were as follows: live mild inflammation, ground glass hepatocytes, hepatic steatosis, and highly expressing of HBcAg mainly in nucleus.
出处
《中西医结合肝病杂志》
CAS
2004年第5期267-269,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
