摘要
目的探讨尿视黄醇结合蛋白(RBP)在早期糖尿病肾病的诊断中的价值。方法用酶联免疫法检测57例糖尿病人及30例正常人尿RBP并进行比较,同时测定24小时尿微量白蛋白(mAlb)。结果在糖尿病无肾病组中,其尿mAlb的含量与正常对照组相比差异无显著性(P>0.05),但其尿RBP的含量明显高于对照组(P<0.01)。在早期糖尿病肾病组和临床糖尿病肾病组中,其尿RBP、mAlb与对照组相比显著升高(P<0.001)。24小时尿mAlb与尿RBP呈正相关(P<0.01)。结论尿RBP可作为诊断早期糖尿病肾病的敏感指标,与尿mAlb比较能更早地反映肾小管功能受损情况。
Objective: To investigate the diagnostic value of urinary retinal binding protein(RBP) in type 2 diabetic nephropathy. Methods: Enzyme linked immunosorbent assay (ELISA) was used for measuring RBP in 30 normal subjects and 57 diabetes, and 24 hours urinary minim albumin(mAlb) was measured by radio immunoassay(RIA). Results: No significant difference of 24 hours urinary mAlb between diabetes patients with no nephropathy and normal subjects(P>0.05), but urinary RBP was much higher than that of normal subjects(P<0.01). Between the early diabetes nephropathy group and clinic diabetes nephropathy group, 24 hours urinary mAlb and urinary RBP was significant difference from normal subjects(P<0.001). 24h urinary mAlb was correlated with urinary RBP(P<0.01). Conclusions: Urinary RBP may be used as the sentitive method for the early stage of diabetes nephropathy, and can be used for reflecting the early damage of renal tubular than urinary mAlb.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第17期128-129,133,共3页
China Journal of Modern Medicine
关键词
糖尿病肾病
视黄醇结合蛋白
diabetes nephropathy
retinal binding protein
