1Mansky KC, Marfatia K, Purdom GH, et al. The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescure of mi mutant osteoclasts. J Leukoc Biol, 2002,71:295-303.
2Matsumoto M, Sudo T, Saito T, et al. Involvement of P38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand( RANKL). J Biol Chem, 2000,275(40) :31155-31161.
3Mizukami J, Takaesu G, Akatsuka H, et al. Receptor activator of NFκB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2,and TRAF6. Mol Cell Biol,2002,22:992-1000.
4Hotokezaka H, Sakai E, Kanaoka K, et al. U0126 and PD98059 specific inhibitors of MEK, accelerate differentiation of RAW 264.7 cells into osteoclast-like cells. J Biol Chem,2002,277:47366-47372.
5Han J, Lee JD, Bibbs L, et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mannalian cells. Science, 1994, 265 (5173): 808-811.
6Li X, Udagawa N, Itoh K, et al. P28MAPK -mediated signals are required for inducing osteoclast differentitation but not for osteoclast function. Endocrinology, 2002,143: 3105-3113.
7Constant SL, DongC, YangDD, et al. JNK1 isrequired forTcell-mediated immunity against Leishmania major infection. J Immunol,2000,165 (5): 2671-2676.
8David JP, Sabapath K, Hoffmann O, et al. JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and-indepondent mechanisms. J Cell Science,2002,115:4317-4325.
9Chikazu D, HzkedaY, OgataN, etal. Fibroblast growth factor (FGF)2 directly stimulates mature osteoclast function through activation of FGFreceptor 1 and P42/44MAP kinase. J Biol Chem,2000,275(42):31444-31450.
10Huber DM, Bendixen AC,Pathrose P,et al. Androgens suppress osteeclast formation induced by RANKL and macrophage-colony stimulating factoe. Endocrinology,2001,1421 (9) :3800-3808.
8Allison P A, Mark E T, Moira G, et at. A RANK/TRAF6- dependent Signal Transduction Pathway Is Essential forOsteoclast Cytoskeletal Organization and Resorp tire Function [J]. J BiolChem, 2002, 277(11): 44347-44356.
9Dougall W C, Glaccum M, Charrier K, et al. RANK is essential for osteoclast and lymph node development [J]. Genes Dev, 1999,13:2412-2424.
10Fata J E, Kong Y Y, Li J, et al. The osteoclast differentiation factor osteoprotegerinligand is essential for mammary gland development[J]. Cell, 2000,103 : 41250.
