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新抗癫癎药影响认知功能的研究进展 被引量：3

Recent advance in effect of new antiepileptic drugs on cognitive function
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摘要 近10年来,对癫癎的研究迅速发展,临床上出现了一批新的抗癫癎药物(AEDs),如奥卡西平、氨己烯酸、拉莫三嗪、唑尼沙胺、加巴喷丁、硫加宾、托吡酯和左乙拉西坦.与传统的抗癫癎药物相比,疗效相似,而耐受性更好.另外几个新抗癫癎药物的疗效相近,治疗谱相似.癫癎患者需要长年用药,甚至终身服药,因此,选择抗癫癎药物主要是基于药物的耐受性、避免对身体和精神的不良反应、防止对患者认知功能的损害.认知功能损害是影响癫癎患者生活质量的主要因素之一.
作者 姚晓东 孙黎 袁孝蓉
机构地区 上海第二医科大学附属仁济医院临床药理药学研究室
出处 《中南药学》 CAS 2004年第4期233-235,共3页 Central South Pharmacy
关键词 新抗癫癎药 认知功能 研究进展 药物副作用 奥卡西平 氨己烯酸 拉莫三嗪
分类号 R971.6 [医药卫生—药品]
  • 相关文献

参考文献20

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同被引文献20

  • 1田国红,赵忠新.左乙拉西坦——一种具有全新作用机制的抗癫痫新药[J].中国新药与临床杂志,2006,25(10):782-786. 被引量：44
  • 2Frank LM ,Enlow T, Holemes GL,et al. Lamictal(lamotrigine) monotherapy for typical absence seizures in children[J]. Epilepsia, 1999,40(7) :973.
  • 3龚耀先.中国修订韦氏儿童智力表(手册)[M].长沙:湖南地图出版社,1993,2.15.
  • 4Prevey ML, Delaney RC, Cramer JA, et al. Complex partial and secondarily generalized seizure patients: cognitive functioning prior to treatmemt with antiepileptic medication. VA Epilepsy Cooperative Study 264 Group [ J ]. Epilepsy Res, 1998, 30(1) :1-9.
  • 5Hermann B, Seidenberg M, Bell B, et al. The neuredevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function[ J]. Epilepsia, 2002,43(9) :1063-1071.
  • 6Cornaggia CM, Gobbi G. Learning disability in epilepsy : definitions and classification[ J]. Epilepsia 2001,42 Suppl 1 : S2-5.
  • 7任榕娜 陈新民 陶其海.儿童长期服用抗癫痫药物对智能的影响[J].实用儿科临床杂志,1994,9(4):223-224.
  • 8Reynolds EN. Anticonvulsants, folic acid, and epilepsy [ J ]. Lancet, 1973,1(7816) :1376-1378.
  • 9胡慧廉,丁乃立,吴莲珍.顶空气相色谱法测定左乙拉西坦中有机溶剂残留量[J].中国新药杂志,2007,16(22):1882-1884. 被引量：5
  • 10丁伯君,邓艳春,张文娟.左乙拉西坦添加治疗难治性癫癎的疗效和安全性分析[J].中国临床神经科学,2011,19(2):189-191. 被引量：23

引证文献3

二级引证文献8

中南药学
2004年 第4期

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