摘要
目的 比较采用常规预防性抗癫痫药和不使用任何预防性癫痫药对 12 13例急性脑挫裂伤患者伤后癫痫发生率的影响。方法 6家医院神经外科共收治符合标准的重型颅脑损伤患者 12 13例 ,分为两组 :①常规采用预防性抗癫痫药组 6 0 7例 ;②不采用预防性抗癫痫药组 6 0 6例。所有患者都经CT扫描证实存在脑挫裂伤。服用常规抗癫痫药物 >18月。伤后临床随访 1～ 8年 ,平均 3.6年。结果 常规预防性抗癫痫药组患者癫痫发生 16例 (2 .6 4 % ) ,不使用任何预防性抗癫癫药组 14例 (2 .31% ) ,两组癫痫发生率无显著差异 (P >0 .0 5 )。结论 采用常规预防性抗癫痫药不能减少脑挫裂伤患者伤后癫痫发生率。
Objective To compare the effect of prophylactic anti-seizure drugs on the occurrence of post-traumatic epilepsy in 1 213 acute traumatic brain injured patients with cerebral contusion. Methods At 6 medical centers, 1 213 patients with cerebral contusion were divided into two groups: prophylactic anti-seizure drugs group (n=607): patients received routinely prophylactic anti-seizure drugs, non-prophylactic anti-seizure drugs group (n=606): patients did not receive any prophylactic anti-seizure drugs after injury. All patients received CT scan to confirm cerebral contusion. The usage duration of anti-seizure drugs was not less than 18 months.Results Patients got 1～8 years' follow-up with a mean of 3.6 years. Sixteen cases of post-traumatic epilepsy occurred in prophylactic anti-seizure drugs group (2.64%), while fourteen cases of post-traumatic epilepsy occurred in non-prophylactic anti-seizure drugs group (2.31%) ( P >0.05). Conclusion The use of prophylactic anti- seizure drugs does not prevent the occurrence of post-traumatic epilepsy, which indicates that prophylactic anti-seizure drugs should not be routinely applied in the patients with acute traumatic brain injury.
出处
《中华神经外科疾病研究杂志》
CAS
2004年第4期301-303,共3页
Chinese Journal of Neurosurgical Disease Research
基金
上海市科委基金重点项目 (9941 1 90 89)
