摘要
[目的]探讨热休克蛋白27(HSP27)表达与大肠癌临床病理参数之间相关性。[方法]应用免疫组化SP法检测72例大肠癌组织和20例癌旁组织HSP27表达情况。[结果]HSP27在癌组织与癌旁组织的表达率分别是40.28%和18.75%,两者差异有统计学意义(P=0.013)。HSP27在高、中、低分化腺癌组织中表达分别是63.64%、35.29%和14.29%,统计学分析三者之间存在显著性差异(P=0.005)。大肠癌组织HSP27表达率与年龄、性别、淋巴结转移、临床分期均无相关性,但在>50岁组中有9例呈过表达(9/23),而≤50岁组中则无过表达者;在伴有淋巴结转移癌组织中HSP27表达率为43.48%,无淋巴结转移者为38.78%,统计学分析虽然无显著性差异,但无淋巴结转移组中HSP27有9例过表达,有淋巴结转移组则无一例过表达。[结论]HSP27参与大肠癌的发生,并与大肠腺癌的病理分级具有相关性。
To investigate the relationship between expression of HSP27 in the colorectal carcinoma and clinicopathological parameters. Seventy-two specimens of carcinoma tissue and 20 transitional mucosas were examined by SP immunohistochemistry staining. The frequency of HSP27 in carcinoma tissues was 40.28%, which significantly higher than that in transitional mucosas (18.75%, P=0.013). The positive rates in the high, moderate and low differentiated tissues were 63.64%, 35.29% and 14.29%, respectively. A statistically significant difference in HSP27 staining was found in relation to histological grade (P=0.005). HSP expression was irrelated to age, gender, lymphatic metastasis and Dukes'stage. Over-expression was found in 9 cases over 50 years old(9/23), and was not found in patient below 50 years old. The positive rate of HSP27 immunostaining was 43.48% in patients with lymphatic metastasis and 38.78% with no lymphatic metastasis. In spite of no statistical difference, HSP27 over-expression was found in cases with lymphatic metastasis, whereas no over-expression was found in patient without lymphatic metastasis. [Conclusion] HSP27 participates in the carcinogenesis of colorectal carcinoma has close relation to histological grade.
出处
《肿瘤学杂志》
CAS
2004年第5期334-336,共3页
Journal of Chinese Oncology
关键词
大肠肿瘤
热休克蛋白
免疫组织化学
基因
colorectal neoplasms
heat shock protein
immunohistochemistry
gene
