摘要
[目的]探讨慢性肾功能衰竭(CRF)患者血清瘦素浓度的变化与脾肾气(阳)虚证的关系。[方法]38例CRF患者中,脾肾气(阳)虚组20例,非脾肾气(阳)虚组18例;另设正常对照组16例。采用酶联免疫吸附法(ELISA法)测定血清瘦素(leptin)水平,同时测定血清白蛋白(ALB)、C反应蛋白(CRP)、前白蛋白(preAlb)等指标,观察CRF患者的血清瘦素水平和客观营养指标与脾肾气(阳)虚证的相关关系。[结果]CRF中脾肾气(阳)虚组血清瘦素水平比非脾肾气(阳)虚组高(P<0.05);脾肾气(阳)虚组的证候评分值同血清瘦素水平呈正相关。脾肾气(阳)虚组血清前白蛋白浓度比非脾肾气(阳)虚组低(P<0.05),而两组的血清白蛋白水平则无显著性差异(P>0.05)。[结论]血清瘦素可能是CRF脾肾气(阳)虚证的部分物质基础,值得做进一步的相关研究。客观营养指标与脾肾气(阳)虚证的关系不太明确,这可能与样本含量太小,Ⅱ类误差增大有关。
[Objective] To investigate the relationship between serum leptin level in chronic renal failure (CRF) and Qi or yang deficiency syndrome of spleen and kidney. [Methods] Thirty-eight cases of CRF and 16 healthy subjects as control were enrolled in this study. The CRF patients were classified as Qi /yang deficiency syndrome of spleen and kidney (pattern 1) and non-Qi/yang-deficiency syndrome of spleen and kidney (pattern 2). Serum leptin level was detected by enzyme-linked immunosorbent assay and nutrient parameters such as serum albumin (ALB), C-reation protein (CRP) and pre;ilbumin (preAlb) levels were also observed. The relationship of leptin level and nutrient parameters with Qi or yang deficiency syndrome of spleen and kidney was observed. [Results] The serum leptin level of pattern 1 was higher than that of pattern 2 ( P < 0.05) and the scoring of pattern 1 was positively correlated with its serum leptin level. Prealbumin level of pattern 1 was lower than that of pattern 2 ( P < 0.05) while albumin level did not differ in the two patterns ( P > 0.05) . [ Conclusion ] Serum leptin may be the partial material base of Qi or yang deficiency syndrome of spleen and kidney and this is worthy doing further research. The uncertain relationship between nutrient parameters and Qi or yang deficiency syndrome of spleen and kidney may be due to the increase of type Ⅱ error which results from the small sample size.
出处
《广州中医药大学学报》
CAS
2004年第4期250-252,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药管理局资助课题(编号:102017)
关键词
慢性肾功能衰竭
血清
瘦素
脾肾气虚证
脾肾阳虚证
RENAL FAILURE, CHRONIC/pathogenesis (tcm)
SPLEEN-KIDNEY YANG DEFICIENCY
LEPTIN/blood
ALBUMINS/blood
