摘要
目的: 探讨米非司酮药流后子宫出血的机理。 方法:采集正常早孕人工流产、药物流产完全与不完全蜕膜组织各20例,应用免疫组化法表达组织中的PR、Fas、LN、FN,应用图象分析仪及半定量方法对表达结果进行观察(P<0.01)。结果: 药流不全组PR、LN的表达均明显高于药流完全组(P<0.05和P<0.01),而Fas表达则明显低于药流完全组(P<0.01)。结论: 药流不全组PR的高表达导致蜕膜组织凋亡障碍,并持续分泌LN致使蜕膜组织粘连不脱落,子宫持续出血,而PR高表达的原因有可能归于使用者的个体差异。
Objective: To investigate the mechanism of prolonged bleeding after mifepristone medical abortion.Methods: Sixty specimens of early pregnant decidual were collected respectively from complete medical abortiongroup, incomplete medical abortion group and termination of pregnancy by curettage group. 20 specimers pergroup. The samples were processed by the SP immunohistochemical techniques to locate PR, Fas, LN, and FN indecidua. Histopathological study was done by light microscopy, and the expressions of PR, Fas, LN and FN indeciduas were observed by semi-quantitative analysis and computed image analysis system. Results: the expres-sion levels of PR and LN between incomplete abortion group and curettage group were significantly higher than thatin the complete abortion group. Fas expression level in incomplete abortion group and curettage group were lowerthan that in the complete abortion group. Conclusion: High expression of PR in incomplete abortion group resistsapoptosis of decidual and secrete LN continiously to adhere decidual, that result in uterus bleeding. The reason forhigh expression of PR may be individual differences.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2004年第3期149-153,i002,共6页
Reproduction and Contraception
基金
北京市自然科学基金资助课题(7982015)
