摘要
为了观察对药"延胡索-冰片"对麻醉犬脑血流动力学的影响,将健康成年家犬30只随机平均分为对照组、对药组、延胡索组、冰片组、阳性对照组,分别灌入蒸馏水、相关药物和常规药物脑心通胶囊,观察实验动物180 min内的血压(BP)、心率(HR)、脑血流量(CBF)和脑血管阻力(CVR)的变化情况,结果显示,对药"延胡索-冰片"能够有效降低实验动物的血压,尤其是在30min内即可迅速起效,作用优于常规药物(P<0.01),但是超过180min后作用有所缓解;对于实验动物的心率无明显影响;能够有效增加试验家犬的脑血流量,尤其是在30 min内即可迅速起效,且效果呈逐渐递增的趋势,作用优于常规药物(P<0.05);对药"延胡索-冰片"能够有效降低家犬的脑血管阻力,尤其是在30min内即可迅速起效,至120 min时达到最佳效果,作用优于常规药物(P<0.05)。本研究显示,对药"延胡索-冰片"能够有效降低血压,减少脑血管阻力,增加脑血流量,调整脑部血管功能,改善脑部血液循环,对于脑组织缺血损伤具有明显保护作用,其起效时间迅速,在30 min左右即可起效,120 min左右达到作用峰值,但是其确切的作用机制有待进一步研究。
To observe the effects of pair herbs'yanhusuo-bingpian'on cerebral blood flow dynamics in anesthetized dogs.30 dogs were randomly divided into the control group,the drug group,yanhusuo group,bingpian group,positive control group,and were drenched with distilled water,related herbs and conventional medicine naoxintong capsule.The changes of blood pressure(BP),heart rate(HR),cerebral blood flow(CBF)and cerebral vascular resistance(CVR)of experimental animal in 180 minute were observed.The results showed that the herbs can effectively reduce the blood pressure of experimental animals,and play a role in 30 minutes,the effect is better than conventional drugs(P<0.01).The herbs have no significant influence of heart rate on experimental animals.The herbs can effectively increase the cerebral blood flow of experimental animals,and play a role in 30 minutes,the effect is better than conventional drugs(P<0.05).The herbs can effectively reduce the cerebral vascular resistance of experimental animals,and play a role in 30 minutes,the effect is better than conventional drugs(P<0.05).The herbs can effectively depress blood pressure,reduce cerebral vascular resistance,increase cerebral blood flow,regulating brain vascular function,improve blood circulation to the brain,and has an obvious protective effect on brain damage.The drug can be effective in about 30 minutes,reached peak in about 120 minutes,but the exact mechanism remains to study further.
出处
《中国兽医学报》
CAS
CSCD
北大核心
2015年第6期995-998,共4页
Chinese Journal of Veterinary Science
基金
高等学校博士学科点专项科研基金资助项目(20122227110003)
吉林省教育厅"十二五"科学技术研究资助项目(吉教科合字[2014]第85号)
吉林省卫生厅科研课题资助项目(2012S007)
关键词
延胡索
冰片
脑血流
动力学
影响
yanhusuo bingpian
cerebral
blood flow
dynamics
influence
