摘要
目的 探讨蛋白C(PC)在急性白血病(AL)合并弥散性血管内凝血(DIC)的诊断和预后中的意义.方法 采用全自动血凝仪对AL合并DIC患者44例和健康体检者30名进行部分活化凝血酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(D-Dimer)和纤维蛋白原(Fbg)含量检测,发色法底物检测抗凝血酶(AT)和PC活性.t检验比较组间凝血、抗凝血和纤溶指标之间的差异性;Pearson相关分析分析各指标与DIC评分之间的相关性.结果 AL合并DIC患者PC活性为67.03±36.98,较对照组的99.53±46.20明显下降,其阳性率达86.36%;PC与DIC评分呈负相关,与疾病的严重性相关.AL合并DIC患者中APTT、PT延长,D-dimer、Fbg升高,AT活性下降,与对照组相比,差异均有统计学意义.结论 AL合并DIC患者存在凝血系统过度活化和纤溶系统异常状态,PC可作为AL合并DIC的敏感指标和预后指标.
Objective To investigate diagnostic and prognostic significance of protein C in acute leukemia with disseminated intravaseular coagnlation(DIC). Methods APTT, P-T, D-Dimer, Fbg, antithrombin (AT) and protein C(PC) were determinated in plasma of 44 DIC patients with acute leukemia and 30 normal controls. Results PC was markedly lower in disseminated intravaseular coagulation with acute leukemia group(67.03±36.98) than that of control group (99.53±45.20), and significantly correlation DIC score( r = -0.57,P＜0.01). PC of abnormality rate in DIC group was 86.36 %. APTT, PT, D-Dimer, Fbg were significantly increased and AT was decreased during the progress of DIC in relation to values observed in the control group. Conclusion DIC is related to the disorder of coagulation and fibfinolysis system. PC is a sensitive index to diagnose and prognose DIC in acute leukemia.
出处
《白血病．淋巴瘤》
CAS
2008年第2期-,共3页
Journal of Leukemia & Lymphoma
