摘要
基于配体交换的机理,研究脯氨酸手性离子液体作为手性配体拆分邻氯扁桃酸对映体的方法及其热力学过程,考察手性离子液体烷基链长、铜离子浓度、离子液体浓度、pH和温度等因素对邻氯扁桃酸对映体分离的影响。研究结果表明:在1-丁基-3-甲基咪唑L-脯氨酸([C4mim][Pro])浓度为6 mmol/L,CuSO4浓度为8 mmol/L,甲醇体积分数为15%,pH为5.1和分离温度为25℃的最优条件下,邻氯扁桃酸对映体可以较好地基线分离,其分离度为1.69;拆分过程是一个放热的焓控过程。
Enantioseparation of 2-chloromandelic acid enantiomers by ligand exchange and its thermodynamical process were studied with chiral ionic liquids(CILs) containing imidazolium cations and L-Proline anions as chiral selector.Some influencing separation factors such as alkyl chain length of CILs,concentrations of Cu2+and CILs,pH and temperature were investigated.The results show that the optimal conditions are as follows: The concentration of [C4 mim][Pro] is 6 mmol/L,the concentration of Cu2+is 8 mmol/L,volume fraction of methanol and water is 15%,pH is 5.1,and the temperature is 25 ℃.Under the optimal conditions,2-chloromandelic acid enantiomers can be baseline separated with a resolution of 1.69.The chiral separation of 2-chloromandelic acid enantiomers is an enthalpy-controlled process.
出处
《中南大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2013年第9期3593-3598,共6页
Journal of Central South University:Science and Technology
基金
国家自然科学基金资助项目(21176262)
湖南省科技计划项目(2010WK3029)
有色金属资源化学教育部重点实验室(中南大学)资助项目(2012)
关键词
手性离子液体
配体交换拆分
热力学
邻氯扁桃酸
chiral ionic liquids
ligand exchange enantioseparation
thermodynamics
2-chloromandelic acid
