摘要
Changes in the activity of Na^+, K^+-ATPase and in the water, sodium, and potassium levels in the ischemic brain were investigated in rabbits 2, 4, and 24h following occlusion of middle cerebral artery (MCAo) and in shamoccluded control. An increase in Na^+, K^+-ATPase activity was observed in 2h and 4h groups, with a subsequent decrease in the enzyme activity. The elevation in Na^+, K^+-ATPase activity was accompanied by an increase in the sodium content and a slight decrease in the potassium content. These changes are presumed to occure because of stimilated active transport of sodium from blood to brain across the brain capillaries. We suggest that the elevated activity of Na^+, K^+-A TPase may participate in the pathogenesis of ischemic brain edema.
Changes in the activity of Na^+, K^+-ATPase and in the water, sodium, and potassium levels in the ischemic brain were investigated in rabbits 2, 4, and 24h following occlusion of middle cerebral artery (MCAo) and in shamoccluded control. An increase in Na^+, K^+-ATPase activity was observed in 2h and 4h groups, with a subsequent decrease in the enzyme activity. The elevation in Na^+, K^+-ATPase activity was accompanied by an increase in the sodium content and a slight decrease in the potassium content. These changes are presumed to occure because of stimilated active transport of sodium from blood to brain across the brain capillaries. We suggest that the elevated activity of Na^+, K^+-A TPase may participate in the pathogenesis of ischemic brain edema.
基金
This work was supported by a grant from National Seventh-Five Year Plan's Cerebrovascular Diseases Research Project
