摘要
检测100例经病理证实的未治疗的食管癌患者免疫指标,包括T_4、T_8、T_4/T_8NK细胞活性、IL-2活性、淋巴细胞转化率和免疫抗体IgG、IgA、IgM。发现食管癌病人的T_4值降低,T_8升高,T_4/T_8倒置;NK活性,IL-2活性和淋巴细胞转化率的为正常人的一半,体液免疫中IgA较明显降低。T细胞亚群的改变与病灶长度和分期有关。
100 patients with esophageal carcinoma were tested for their immunological parameters which included lymphocyte subsets of T3, T4, T8, T4/T8, IL-2, NK cell activity ,lymphocyte transfer rate and IgG, IGA, IgM. The results showed that the percent of T4, T4/T8, L-2 NK cell activity and lymphocyte transfer rate decreased markedly in these patients as compared with those of normal controls. Moreover, above reduced parameters were related to the length of lesion and the stage of disease These findings may indicate that the immunological status in esophageal cancer patients are suppressed which may be responsible for its poor prognosis.
出处
《中华放射肿瘤学杂志》
CSCD
1992年第3期34-37,69,共5页
Chinese Journal of Radiation Oncology
