摘要
目的探讨肝细胞性肝癌(HCC)的葡萄糖代谢与血清甲胎蛋白(AFP)之间的关系。方法45例经组织病理学检查证实的HCC患者行全身18F-FDG PET显像。测定肿瘤病灶的葡萄糖标准摄取值(SUV)、肿瘤与非肿瘤区SUV比值,分析二者同AFP之间的关系。结果45例HCC患者中,43例肝内原发病灶及转移的淋巴结其PET显像表现为异常放射性浓聚灶,2例高分化HCC显像结果阴性。线性结果分析表明,AFP同SUV、SUV比值之间存在一定的相关性,r值分别为0.426(P<0.05)和0.532(P<0.001)。结论HCC 18F-FDG PET显像测得的SUV及SUV比值同血清AFP之间存在显著的相关关系,表明AFP同肿瘤细胞的增殖及代谢有相关性。
Objective To investigate whether 18 F-fluorodexyglucose (FDG) uptake in the primary hepatocellular carcinoma (HCC) correlates with serum α-fetoprotein (AFP). Methods Forty-five patients with histologically confirmed HCC underwent whole-body 18 F-FDG PET examination. Standardized uptake value (SUV) and tumor-to-nontumor ratio of the SUV (SUVratio) were calculated, and the relationship between serum AFP and glucose metabolism in HCC was analyzed. Results Of the 45 cases, the primary tumor and metastatic lymph nodes were clearly displayed on PET images in 43 cases and the well- differentiated tumors were shown negative in the other 2 cases. A linear correlation of the AFP with SUV (r=0.426, P<0.05) and SUVratio (r=0.532, P<0.001) was noted. Conclusion Serum AFP correlates significantly with both SUV and SUN ratio, indicating that AFP is involved in glucose metabolism and cell proliferation in HCC.
出处
《第一军医大学学报》
CSCD
北大核心
2004年第6期697-699,共3页
Journal of First Military Medical University
