摘要
目的 观察在系膜增殖性肾炎 (MesPGN)患者中血管紧张素转换酶抑制剂 (ACEI)治疗时血浆IL 8的变化 ,探讨ACEI减轻肾小球硬化的机制。方法 用双抗夹心酶联免疫吸附法测定 2 3例MesPGN患者接受ACEI治疗前、后及 15名健康志愿者的血浆IL 8的含量 ,并进行比较。结果 MesPGN患者血浆IL 8、血管紧张素Ⅱ (AⅡ )水平明显高于对照组 (P <0 .0 1)。经ACEI治疗 3个月后 ,MesPGN患者血压、蛋白尿均有明显改善 ,血浆IL 8、AⅡ水平较治疗前显著下降 (P <0 .0 1) ,且血浆IL 8含量的下降与AⅡ水平下降呈正相关 (r =0 .43 7,P <0 .0 5 )。结论 ACEI可能通过降低血浆IL 8水平 ,减轻肾小球炎症反应 。
Objective To explore the mechanism of angiotensin converting enzyme inhibitor's (ACEI) inhibition on glomerular sclerosis by investigating the effects of ACEI on interleukin 8 (IL 8) in mesangial proliferative glomerulonephritis (MesPGN).Methods MesPGN patients' plasma IL 8 was measured before and after the treatment of ACEI by ELISA. Plasma AⅡ was measured by RIA.Results Plasma IL 8 and AⅡ increased significantly in MesPGN group compared with the control group( P <0.01). After the 12 week treatment of ACEI, plasma IL 8 and AⅡ were obviously decreased( P < 0.01 ). The decrease of plasma IL 8 had present positive correlation with that of plasma AⅡ( r =0.437, P <0.05).Conclusion Possibly by means of decreasing plasma IL 8, ACEI can alleviate the inflammation reaction of glomerulus as well as inhibiting the proliferation and sclerosis.
出处
《临床内科杂志》
CAS
北大核心
2002年第S1期82-84,共3页
Journal of Clinical Internal Medicine
