摘要
目的 :评价早期干预对改善缺氧缺血性脑病 (HIE)患儿智力发育的效果 ,并观察早期干预对HIE患儿肌力发育、骨密度、骨结构和骨量储备情况 .方法 :将 6 4例HIE患儿随机分为干预组 (34)例和常规育儿组 (30 )例 ,另设同期正常新生儿 (38)例为对照组 .干预组从新生儿期开始接受为期 0～ 1 8mo的以“专业指导和家庭互动”为中心的干预治疗 .所有病例均于生后每隔 3mo进行智能发育检测和骨强度测定 .结果 :①干预组 6mo ,1岁和 1 .5岁时智力发育指数 (MDI)、心理运动发育指数 (PDI)比常规育儿组高 (P <0 .0 5 )且与正常对照组无显著性差异 (P >0 .0 5 ) .②干预组 1岁、1 .5岁时骨强度(SOS)值比常规育儿组高 (P <0 .0 5 ) ;比正常对照组高 (P <0 .0 5 ) .结论 :①早期干预可促进HIE患儿智力发育 ,有效地防治HIE所致的后遗症 ;②早期干预不仅可提高智能 ,还可促进患儿肌力发育 ,加强骨密度。
AMI: To evaluate the effects of early intervention on the mental development, myodynamic development, bone density, bone structure and bone reserves in children with hypoxic ischemic encephalopathy (HIE). METHODS: Among the 64 HIE children, 34 were randomly chosen to undergo 18 month intervention, which was characterized with “professional guidance and family involvement” and the other 30 children received routine nursing. At the same time, another 38 normal children about the same age as HIE group were assigned as the control. Tests on mental development and determination of bone density were given to each child every 3 months. RESULTS: ① HIE children with early intervention exhibited significantly higher MDI and PDI than those without intervention ( P <0.05), while no significant difference was found compared with the control ( P >0.05). ② SOS of HIE children with early intervention at the age of 1 year and 1.5 years was higher than that of those without intervention and the control. ③ Among the HIE children, 95% of those with early intervention recovered, while only 61% of those without early treatment recovered. CONCLUSION: ①Early intervention can help HIE children in their mental development and prevent sequela of HIE; ② Early intervention is also proved to be effective in the improvement of mental development, myodynamic development, bone density, bone structure and bone reserves.
出处
《第四军医大学学报》
北大核心
2004年第11期1053-1055,共3页
Journal of the Fourth Military Medical University
关键词
新生儿
缺氧缺血性脑病
早期干预
智力
骨密度
infant, newborn
HIE
Early training
intelligence
bones intensity test
