摘要
目的 探讨长春新碱血管外渗局部组织损伤防护的理想处理方法。方法 用 2 1只新西兰大白兔 ,按临床常用 1.5倍药物浓度将每只兔制作 4个部位长春新碱 (VCR)静脉外渗模型。局部分别用云南白药加 5 0 %乙醇膏湿敷、海普林软膏涂擦、5 0 %硫酸镁湿敷和不使用任何药物 4种方法进行对比 ,不同时期行肉眼和组织病理变化观察。结果 4组间 3d无差异 ,7d充血、水肿、炎细胞浸润消退 ,以云南白药乙醇组为优 ,海普林组次之。硫酸镁组对组织水肿有疗效 ,其他与对照组无差异。结论 云南白药乙醇、海普林外敷对VCR血管外渗有良好的防护作用。5 0 %硫酸镁外敷仅能减轻充血 。
Objective Search the ideal treatment of prevention of local tissue damage of VCR vassular exosmosis.Method Use 21 New Zealand big white rabbits, and make 4 locuses of each one as VCR vein exosmosis models according to the clinical frequently used 1.5 times medicine concentration. Make contrast among 4 groups of local treatment: wet compress with Yunnanbaiyao and 50 percent ethanol past, inunction with Heptaverine ointment, wet compress with 50 percent magnesium sulfate, and no drugs; make observation in varying periods by naked eyes and tissue pathological changes.Result There is no difference among 4 groups in 3 days , about extinction of hyperemia, edema, inflammatroy infiltration within 7 days, the group of Yunnanbaiya and ethaol is superior, the group of Heptaverine takes the second place.The group of magnesium sulfate produces the curative effect to tissue edema, but has no difference with other contrastive groups.Conclusion External compress of Yunnanbaiyao, ethanol and Heptaverine has a good prevention to VCR vascular exosmosis , external compress of 50 percent magnesium salfate only alleviates hyperemia but has no prevention.=
基金
河南大学自然科学基础研究资助课题 (XK 0 10 16)
关键词
血管外渗
长春新碱
云南白药
硫酸镁
海普林
vascular exosmosis
vincristine
yunnanbaiyao
magnesium sulfate
Heptaverine
