摘要
本文通过共沉淀法,合成了两水亲性嵌段共聚物聚(乙烯吡咯烷酮)-b-聚(苯乙烯-alt-马来酸酐)(PVP-b-PSMA)修饰的Fe3O4磁纳米粒子。并利用动态光散射法(DLS)、X射线粉末衍射(XRD)和扫描电镜(SEM)对磁纳米粒子进行表征。结果表明,嵌段共聚物修饰的Fe3O4磁纳米粒子与纯Fe3O4磁纳米粒子比较,分布更分散,为大小均匀的球状颗粒,其粒径在100nm左右。振动样品磁强计(VSM)测试结果显示,在室温、外加磁场下,该磁纳米粒子呈现超顺磁性,其饱和磁化强度为55emuΠg。以上结果表明Fe3O4磁纳米粒子有望应用于磁靶向药物控释、热疗、酶的固定、生物分离等生物医学领域。
Double-hydrophilic block copolymer poly(N-vinylprrolidone)-block-poly(styrene-alter-maleic anhydride)(PVP-b-PSMA)modified Fe3O4 magnetic nanoparticles were prepared by co-precipitation method.The samples were then characterized by dynamic light scattering(DLS),scanning electron micrographs(SEM)and X-ray diffraction(XRD)analysis.It was demonstrated that the copolymer modified magnetic nanoparticles,compared with Fe3O4nanoparticles,has well-defined spherical shape with mean hydrodynamic diameter around 100nm.Vibrating sample magnetometer(VSM)indicated the magnetic nanoparticles superparamagnetic at room temperature under an applied magnetic field.The saturated magnetization was measured to be 55emuΠg.All result showed that Fe3O4 magnetic nanoparticles may be used in various biomedical applications such as targeted drug delivery,hyperthermia, enzyme immobilization,biological separation.
出处
《材料科学与工程学报》
CAS
CSCD
北大核心
2014年第3期385-388,392,共5页
Journal of Materials Science and Engineering
基金
国家自然科学基金资助项目(50273010)
河南省教育厅科学技术研究重点资助项目(12A150005)
关键词
FE3O4
磁纳米粒子
两水亲性嵌段共聚物
共沉淀
Fe3O4
magnetic nanoparticles
double-hydrophilic block copolymers
co-precipitation
