摘要
目的 探讨白细胞滤过输血对待肾移植患者产生HLA抗体的影响及巨细胞病毒 (CMV)感染率的降低程度。方法 选择 16 6例待肾移植患者进行临床输血观察 ,其中 92例进行白细胞滤过输血 ,74例进行浓缩红细胞输注。结果 白细胞滤过组 ,HLA抗体阳性率 1.1% ,巨细胞病毒感染率 3.2 % ;未滤过组HLA抗体阳性率 9.5 % ,巨细胞病毒感染率 13.5 % ;两者差别有高度显著性 (P <0 .0 1)。结论 白细胞滤除输血 ,能够有效预防HLA抗体产生 ,减少肾移植术后CMV感染 ,对确实需输血的待肾移植患者提供了一条安全有效的输血途径和措施。
Objective To investigate the effect of HLA-IgG and cytomegalovirus infection about transfusion of leukocyte filtering on the patients waiting for kidney transplantation. Methods A total of 166 patients waiting for kidney transplantation were divided into two groups, 92 cases were transfusion of leukocyte filtering, 74 cases were transfusion of concentrated red cells. Results In leukocyte filtering group,the HLA antibody positive rate 1.1%,the cytomtgalovirus infection rate is 3.2 %,the non-filtering group HLA antibody positive rate is 9.5%,the cytomegalovirus infection rate is 13.5%,there's obvious difference between them(P<0.01). Conclusion This method can effectively prevent HLA antibody production,lessen CMV infection.It was a security transfusion pathway to the patient waiting for kidney transplantation by transfusion of leukocyte filtering.
出处
《医药论坛杂志》
2004年第13期19-20,22,共3页
Journal of Medical Forum
关键词
输血
白细胞滤过
肾移植HLA抗体
巨细胞病毒感染
Transfusion
Leukocyte filtering
Kidney transplantation
HLA antibodies
CMV infection
