摘要
目的探讨高龄喉癌患者手术治疗疗效的相关因素。方法以100例行喉癌切除术的高龄喉癌患者作为研究对象,采用Kaplan-Meier法计算出生存率,采用Log-rank法进行单因素分析及应用Cox比例风险回归模型进行多因素分析。结果 100例高龄喉癌患者手术治疗后全部获得随访,1、3、5年生存率分别为89.0%、73.0%和61.0%。单因素分析结果显示:肿瘤原发部位、淋巴结转移、肿瘤大小、是否行颈部淋巴结清扫、T分期、N分期、病理分级对患者术后疗效的影响显著(P<0.05),而患者性别、年龄、手术方式与其术后疗效无相关性(P>0.05);多因素分析结果显示:T分期、N分期和淋巴结转移是影响高龄喉癌患者手术疗效的独立危险因素。结论影响高龄喉癌患者术后疗效的独立危险因素是T分期、N分期和淋巴结转移。
Objective To explore the related factors influencing efficacy of surgical treatment for laryngeal cancer . Methods 100 cases of elderly patients with laryngeal cancer who underwent laryngectomy were selected as the research object , the Kaplan Meier-method was used to study survival rate .Log-rank was used to perform single factor analysis and the Cox propor-tional hazards regression model was used to perform multiple factors analysis .Results 100 patients received follow-up,1,3, 5year survival rates were 89.0%,73.0% and 61.0%,respectively.Single factor analysis showed that primary site of tumor , lymph node metastasis,tumor size,whether underwent neck lymph node dissection ,T stage,N stage and pathological classification were significant factors influencing postoperative efficacy (P<0.05),while gender,age and operation method were not related with postoperative efficacy (P>0.05);Multi-factor analysis showed that the T stage ,N stage and lymph node metastasis were in-dependent risk factors affecting curative effect of elderly patients with laryngeal cancer .Conclusion The independent risk factors affecting the postoperative curative effect of elderly patients with laryngeal cancer are T stage ,N stage and lymph node metastasis .
出处
《实用癌症杂志》
2014年第2期154-156,共3页
The Practical Journal of Cancer
关键词
喉癌
手术治疗
生存率
预后
影响因素
高龄患者
Laryngeal cancer
Surgical treatment
Survival rate
Prognosis
Influencing factors
Elderly patients
