摘要
目的:探讨乙肝肝硬化患者FIB-4指数与Child-Pugh分级之间的相关性,了解其评估乙肝肝硬化患者病情严重程度及预后的能力。方法:回顾性分析112例乙肝肝硬化住院患者,按Child-Pugh分级分为A、B、C三组,根据患者年龄、ALT、AST及血小板计数计算其FIB-4指数,评估各组间FIB-4指数差异性,并采用Spearman's等级相关性分析研究FIB-4指数与Child-Pugh分级之间的关系。结果:乙肝肝硬化患者按Child-Pugh分级分组后比较3组间FIB-4指数差异均有统计学意义(P<0.01);患者FIB-4指数与Child-Pugh分级呈显著正相关(r=0.817,P<0.01)。结论:乙肝肝硬化患者FIB-4指数与Child-Pugh分级之间呈正相关,FIB-4指数测定可作为客观评估乙肝肝硬化患者病情严重程度及预后的有效工具。
Objective To investigate the correlation between FIB-4 index and Child-Pugh classification in patients with HBVrelated cirrhosis.Methods The clinical data of 112 patients with HBV-related cirrhosis were restrospectively analyzed.The patients were divided into three groups(group A,B,C) according to Child-Pugh classification.FIB-4 index were calculated based on age,levels of ALT and AST,platelet counts.The Spearman's rank correlation was used to analyze the relationship between FIB-4 index and Child-Pugh classification.Results There was a significant difference in the FIB-4 index among group A,B and C(all P < 0.01).The Spearman's rank correlation analysis demonstrated that the coefficient correlation between FIB-4 index and Child-Pugh classification was 0.817(P < 0.01).Conclusion The FIB-4 index is closely correlated to Child-Pugh classification in patients with HBV-related cirrhosis.The FIB-4 index is a simple,objective and effective method for assessing the severity and prognosis of patients with HBV-related cirrhosis.
出处
《湖北医药学院学报》
CAS
2013年第3期245-247,共3页
Journal of Hubei University of Medicine
