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胶质瘤切除术对神经胶质瘤患者外周血淋巴细胞亚群及CD4^+CD25^+调节性T细胞的影响 被引量：4

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摘要 目的检测神经胶质瘤患者胶质瘤切除前后外周血淋巴细胞亚群及CD4+CD25+调节性T细胞,以期提供胶质瘤治疗的新思路。方法采用流式细胞术检测神经胶质瘤患者胶质瘤切除前后及正常人外周血中CD3+、CD3+CD4+、CD3+CD8+、CD4/CD8、CD3-CD16+/CD56+、CD3+HLA-DR+和CD4+CD25+调节性T细胞水平。结果与对照组比较,胶质瘤组CD4+/CD8+比值、CD3+CD4+、CD3-CD19+、CD3-CD16+/CD56+和CD3+HLA-DR+细胞百分比明显降低(P<0.05),CD3+细胞及百分比降低,但无显著性差异(P>0.05),CD3+CD8+细胞有所升高,但无显著性差异(P>0.05),CD4+CD25+明显升高(P<0.05);与胶质瘤切除术前组比较,术后组CD4+/CD8+比值、CD3+CD4+、CD3-CD16+/CD56+、CD3+HLA-DR+细胞百分比明显升高(P<0.05),CD3+细胞及CD3-CD19+百分比升高,但无显著性差异(P>0.05),CD3+CD8+、CD4+CD25+明显降低(P<0.05)。结论手术切除胶质瘤能明显降低CD4+CD25+调节性T细胞水平,减少对其他淋巴细胞的抑制作用,如同时辅以CD25抗体来清除掉一部分调节细胞也许会更进一步减少其对机体免疫功能的抑制,这或许为胶质瘤的治疗提供了一个新途径。
作者 马学华 张萱 滕雷 关秀茹 崔兰英 韩伟
机构地区 哈尔滨医科大学附属第一医院
出处 《黑龙江医学》 2013年第4期241-244,共4页 Heilongjiang Medical Journal
基金 黑龙江省教育厅基金资助项目(11521105)
关键词 神经胶质瘤 流式细胞术 淋巴细胞亚群 CD4+ CD25+调节性T细胞
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献13

同被引文献35

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引证文献4

二级引证文献10

黑龙江医学
2013年 第4期

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