摘要
目的:观察咳喘顺丸对慢性支气管炎模型小鼠的作用,为其临床应用提供药理学依据。方法:将实验动物随机分为正常对照组、模型对照组、阳性药组、咳喘顺丸低、中、高剂量组,采用烟熏诱导慢性支气管小鼠模型,光镜下观察各组的气管和肺组织的病理形态学变化;采用大鼠棉球肉芽肿模型、二甲苯致小鼠耳廓肿胀、蛋清致大鼠足趾肿胀模型,观察研究咳喘顺丸的抗炎作用。结果:与模型组相比,咳喘顺丸各剂量组气管和肺组织病理损伤较模型组减轻;与对照组比较,咳喘顺丸中、高剂量均能够显著减轻二甲苯所致小鼠耳廓肿胀(p<0.05～0.01);咳喘顺丸中、高剂量能够抑制大鼠蛋清致炎后2 h的足肿胀(p<0.05)。结论:咳喘顺丸能减轻慢性支气管小鼠模型气管和肺组织的损伤程度,具有一定的抗炎作用。
Objective:To investigate the effects of Kechuanshun pills on the mice with chronic bronchitis,then provide a pharmacology basis for its clinical application. Method: Smoke was used to develop chronic bronchitis mice mode. The experimental animals were randomly divided into normal control group, model group, Kechuanshun pill low-dose group, middle- dose group and high-dose group. The pathomorphology changes in bronchus and lung tissue were observed with the electron microscope. The model of rat cotton pellet granuloma, xylene-induced ear edema in mice and edema of rat hind paw induced by egg albumin in rats were used to observe the anti-inflammatory effects of Kechuanshun pills. Result:Compared with the model group, pathological damages of bronchus and lung tissue were lighter in Kechuanshun pills treatment groups. Compared with the control group, Kechuanshun pills middle-dose group and high-dose group could significantly inhibit the edema induced by xylene (p <0.05～0.01) and decrease the edema of rat hind paw(p<0.05).Conclusion: Kechuanshun pills can reduce pathological damages of bronchus and lung tissue and have the action of anti-inflammatory.
出处
《中药与临床》
2012年第6期35-39,共5页
Pharmacy and Clinics of Chinese Materia Medica
关键词
咳喘顺丸
慢性支气管炎
抗炎
Kechuanshun pills
chronic bronchitis
anti-inflammatory
