摘要
目的 观察复方红景天提取物对大鼠+Gz暴露后血清超氧化物歧化酶(superoxide dismutase,SOD)活性和丙二醛(malondialdehyde,MDA)含量的影响. 方法 雄性SD大鼠72只,按体重编号随机分为6组:正常对照组、捆绑组、+10 Gz组、复方红景天低(0.75 g/kg)、中(1.5 g/kg)、高(3.0 g/kg)剂量组,每组12只.复方红景天组给予相应剂量的复方红景天提取物灌胃,其他各组给予蒸馏水灌胃,连续14d.14d后,正常对照组不做处理,捆绑组动物只做捆绑应激,其他4组均进行+10 Gz暴露.暴露后,迅速处死动物并收集血清进行SOD活性、MDA含量检测. 结果 大鼠体重均增加,各组之间无统计学差异.与正常对照组比,捆绑组、+10 Gz组、复方红景天低剂量组、中剂量组的SOD活性均明显降低(P＜0.01),高剂量组SOD活性变化不明显.中、高剂量组SOD活性明显高于捆绑组和+10 Gz组(P＜0.01).与+10 Gz组比,中剂量组MDA含量明显降低(P＜0.05),其他各组MDA含量无明显变化. 结论 中等剂量的复方红景天可增加+Gz暴露后大鼠血清SOD活力,降低MDA浓度；对+Gz所致机体氧化应激损伤具有防护作用.
Objective To observe the effects of extracted compound rhodiola on superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the serum of rat after + Gz exposure.Methods Seventy-two male SD rats were averagely divided into six groups:normal control group,binding group,+10 Gz group and compound rhodiola extract low,middle,and high dosage groups with extracted compound rhodiola.The low,middle,and high dosage group was respectwely administrated with the dosages of 0.75 g/kg,1.5 g/kg and 3.0 g/kg and the others were given distilled water.Except normal control group and binding group,the other groups were exposed to+10 Gz after daily intragastric administration for 14 days.The serum of rats was collected,and its SOD activity and MDA content were determined subsequently.Results The weight of rats increased significantly and there was no statistical difference among all the groups.Compared with normal control group,SOD activity of high dosage group was slightly changed but the other group's was decreased significantly (P＜0.01).Compared with binding group and+ 10 Gz group,SOD activity of middle and high dosage group was increased obviously (P＜0.01).MDA content of middle dosage group was significantly decreased after +10 Gz exposure.Conclusions Compound rhodiola can increase SOD activity and decrease MDA content of rat serum after+Gz exposure.The results indicate that compound rhodiola would be effective in protecting +Gz induced organism damage.
出处
《中华航空航天医学杂志》
CSCD
2012年第3期188-191,共4页
Chinese Journal of Aerospace Medicine
基金
国家科技重大专项课题
