摘要
为了寻求广谱、高效、安全的鱼尼丁受体作用剂,设计并合成了9个邻氨基N-甲氧基苯甲酰胺类化合物。其结构经1H NMR、HPLC-Mass和IR分析确证。初步生物活性测试表明:目标化合物在100 mg/L浓度下对鳞翅目粘虫(Mythimna separata)有100%的致死率。在500 mg/L浓度下,大多化合物对同翅目的豆蚜(Aphis fabae)以及叶蝉(Nephotettix cincticeps)具有显著的活性,如化合物11a、11c、11e和11g对蚜虫的活性在90%以上,化合物11e和11i对叶蝉的活性达到了100%。在500 mg/L浓度下,目标化合物对螨虫红蜘蛛(Tetranchus urticae)没有表现出明显活性。
To seek for broad spectra,high efficiency and safe pesticides which work on ryanodines receptor,nine novel N-methoxyl-o-aminobenzamide derivatives were designed and synthesized.Their structures were confirmed by 1H NMR.The preliminary bioactivity evaluation showed that the compounds had 100% insecticidal activities against lepidopte ranpests Mythimna separata at 100 mg/L.At 500 mg/L,most of the compounds exhibited good activities against Homopteran pests Aphis fabae and mite Nephotettix cincticeps.For example,compounds 11a,11c,11e and 11g showed more than 90% insecticidal activities against Aphis fabae;the compound 11e and 11i showed 100% insecticidal activities against Nephotettix cincticeps.All of the title compounds exhibited no acaricidal activities against mite at 500 mg/L.
出处
《精细化工中间体》
CAS
2012年第2期9-13,共5页
Fine Chemical Intermediates
基金
国家重点基础研究发展计划(973)项目(2010CB126104)
"十二五"国家科技支撑计划课题(2011BAE06B01)
湖南省自然科学基金(11JJ2006)
