摘要
目的通过对首发、未用药的重性抑郁障碍患者进行3.0T磁共振扫描,寻找重性抑郁障碍患者大脑灰质体积的异常改变,探讨大脑结构异常在重性抑郁障碍患者发病机制中的作用及其病理生理学意义。方法应用基于体素的形态学测定法,对35例首发、未用药的重性抑郁障碍患者和35例正常对照者的3.0T三维脑结构磁共振图像进行全脑灰质体积的分析,对两组研究对象灰质体积差异进行比较。结果对全脑灰质体积研究结果表明,与正常对照组相比,重性抑郁障碍患者右侧额叶中央前回、左侧颞叶颞下回、右侧顶叶中央后回、左侧顶叶中央旁小叶和左侧后扣带回灰质体积显著降低(均P<0.05)。结论首次发病、未经治疗的重性抑郁障碍患者存在额叶、顶叶、颞叶、扣带回等多个部位灰质体积减小。提示重性抑郁障碍的发病机制可能涉及多个脑区,不同脑区之间神经环路的异常可能在重性抑郁障碍的发病机制中起关键作用。
Objective To research the changes of regional gray matter volumes in first-episode,medication naive patients with major depressive disorder.Methods 3.0 T Magnetic resonance imaging and voxel-based morphometry were used to compare regional gray matter volumes between 35 medication-naive participants with a first episode of major depressive disorder(MDD) and 35 healthy comparison participants(HC).Results Volumes of frontal lobe,parietal lobe and posterior cingulated were significantly smaller in the MDD group than in the HC group.Conclusions These results suggest that volume reductions in frontal lobe,parietal lobe and posterior cingulated in patients with MDD are present at illness onset.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第10期2926-2929,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
抑郁症
磁共振成像
神经通路
Depressive disorder
Magnetic resonance imaging
Neural pathways
