摘要
2,6,6-三甲基-1-环己烯-1-甲醛与(3-甲氧基-2-甲基烯丙基)膦酸二乙酯经Wittig-Horner缩合制得1-甲氧基-2-甲基-4-(2,6,6-三甲基-1-环己烯-1-基)-1,3-丁二烯,然后经酸催化水解得到维生素A的关键中间体2-甲基-4-(2,6,6-三甲基-1-环己烯-1-基)-2-丁烯醛,总收率约47%。
2,6,6-Trimethyl-1-cyclohexen-1-aldehyde underwent Wittig-Horner condensation with(3-methoxy-2-methylallyl)phosphonic acid diethyl ester to obtain 1-methoxy-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-butadiene,which was subjected to hydrolysis catalyzed by acid to obtain 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal,the key intermediate of vitamin A.The overall yield was about 47%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第6期410-411,共2页
Chinese Journal of Pharmaceuticals
基金
国家火炬计划项目(2006GH020636)
