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Effect of 5-Aza-2'-deoxycytidine on the P16 tumor suppressor gene in hepatocellular carcinoma cell line HepG2 被引量：21

Effect of 5-Aza-2'-deoxycytidine on the P16 tumor suppressor gene in hepatocellular carcinoma cell line HepG2
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摘要 INTRODUCTIONHepatocellular carcinoma (HCC) is one of the mostcommon human malignancies worldwide[1,2], and isclosely associated with infection of HBV and HCVand contamination of aflatoxin B1[3-6]. Althoughthe molecular mechanisms of hepatocarcinogenesisremain poorly understood, an increasing number ofgenetic abnormalities have been recognized[7-10],for example, the p16 gene[11,12] the p53gene[13-18], the E-cadherin gene[19], and the c-mycgene[20].
作者 Li Hua Liu1 Wen Hua Xiao2 Wei Wen Liu3 1Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China (now working in Department of Gastroenterology, General Hospital of PLA, Lanzhou 730050, Gansu Province, China)2Department of Oncology3Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第1期131-135,共5页 世界胃肠病学杂志（英文版）
基金 Project supported partly by the National Natural Science Foundation of China, No. 39870344
关键词 Carcinoma Hepatocellular Liver Neoplasms Antimetabolites Antineoplastic AZACITIDINE derivatives Carcinogenicity Tests Cell Cycle Cyclin-Dependent Kinase Inhibitor p16 DNA Methylation Flow Cytometry Gene Expression Regulation Neoplastic Humans RNA Messenger Research Support Non-U.S. Gov't Tumor Cells Cultured liver neoplasms genes, p16 methylation, genes, suppressor, tumor, flow cytometry immunohistochemistry polymerase chain reaction
分类号 R735.7 [医药卫生—肿瘤]
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  • 1Juan M. Zapata,Maryla Krajewska,Stanislaw Krajewski,Ruo-Pan Huang,Shinichi Takayama,Hong-Gang Wang,Eileen Adamson,John C. Reed.Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors[J]. Breast Cancer Research and Treatment . 1998 (2)
  • 2Kokura K,Nakadai T,Kishimoto T,Makino Y,Muramatsu M,Tamura T.Gene expression in hepatomas. Journal of Gastroenterology . 1998
  • 3Li R,Waga S,Hannon GJ,et al.Differential effects by the p21 CDK inhibitor on PCNA dependent DNA replication and repair. Nature . 1994
  • 4Tang ZY,Yu YQ,Zhou XD,Ma ZC,Wu ZQ.Progress and prospects in hepatocellular carcinoma surgery. Annales de Chirurgie . 1998
  • 5Andrew H.Wyllie.Apoptosis and carcinogenesis. European J Cell Biology . 1997
  • 6Kidd VJ.Proteolytic activities that mediate apoptosis. Annual Review of Physiology . 1998
  • 7Kitada,S.,Andersen,J.,Akar,S.,Zapata,J.M.,Takayama,S.,Krajewski,S.,Wang,H.G.,Zhang,X.,Bullrich,F.,Croce,C.M.,Rai,K.,Hines,J.,Reed,J.C.Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood . 1998
  • 8Estrov Z,Thall PF,Talpz M,et al.Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia. Blood . 1998
  • 9Krajewski,S,Gascoyne,RD,Zapata,JM,Krajewska,M,Kitada,S,Chhanabhai,M,Horsman,D,Berean,K,Piro,LD,Fugier-Vivier,I,Liu,Y-J,Wang,H-G,Reed,JC.Immunolocalization of the ICE/Ced-3-family protease, CPP32 (caspase-3) in non-Hodgkin’s lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes. Blood . 1997
  • 10Chhanabhai,M,Krajewski,S,Krajewska,M,Wang,HG,Reed,JC,Gascoyne,RD.Immunohistochemical analysis of interleukin-1β-converting enzyme/Ced-3 family protease, CPP32/Yama/caspase-3, in Hodgkin’s disease. Blood . 1997

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World Journal of Gastroenterology
2001年 第1期

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