摘要
[目的]探讨胸腔内分别注入白介素-2、博来霉素、顺铂治疗恶性胸腔积液的疗效与毒副反应。[方法]回顾性分析经胸水细胞学确诊为恶性胸腔积液的患者共216例:白介素-2组(A组)80例,胸腔内注入0.9%生理盐水20ml+白介素-2100万U;博来霉素组(B组)72例,胸腔内注入0.9%生理盐水20ml+博来霉素60mg;顺铂组(C组)64例,胸腔内注入0.9%生理盐水20ml+顺铂60mg;间隔1周重复上述治疗,其中白介素-2组每4～5d重复治疗,最多重复4次。观察3组疗效、毒副反应。[结果]A、B、C组总有效率分别为75.0%、70.8%和56.3%,3组比较差异无统计学意义(P>0.05)。治疗后A组寒战、骨髓抑制、消化道反应、胸痛发生率均明显低于B、C组,差异有显著性(P<0.01)。[结论]胸腔内注射白介素-2治疗恶性胸腔积液疗效较好,毒副反应较博来霉素组、顺铂组明显轻,局部刺激较轻,耐受性好,是治疗恶性胸腔积液较好的方法。
[Purpose] To investigate the response and toxicity of interleukin-2, bleomycin or cisplatin in patients with malignant pleural effusion. [Methods] Two hundred and sixteen cases with malignant pleural effusion were analyzed retrospectively. Interleukin-2 (group A) group was 80 cases with 1000000 U interleukin-2; bleomycin group (group B), 72 cases with bleomycin 60mg;cisplatin group (group C) , 64 cases with cisplatin 60mg intrapleurally, every other week except interleukin-2 for every 4～5d repeat, no more t...
出处
《肿瘤学杂志》
CAS
2009年第10期940-942,共3页
Journal of Chinese Oncology
关键词
恶性胸腔积液
白介素-2
顺铂
博来霉素
malignant pleural effusion
interleukin-2
cisplatin
bleomycin
