摘要
目的探讨MMP2、MMP9和TIMP1在心力衰竭中的作用和阿托伐他汀治疗心衰的效果。方法用大耳兔做动物模型分3组,假手术(SO)组、心衰对照(HC)组、心衰阿托伐他汀干预(HA)组,HC组与HA组建立心衰模型,造模后6周给予HA组阿托伐他汀干预,用ELISA方法测定术前、术后6周及给药4周后血清中MMP2、MMP9和TIMP1的浓度。结果术前三组兔子MMP2、MMP9和TIMP1的水平,差异无统计学意义(P>0.05)。术后6周,HC组与HA组的MMP2、MMP9和TIMP1的水平均高于SO组,差异有统计学意义(P<0.05)。HA组给药4周后,MMP2、MMP9和TIMP1的水平明显低于HC组(P<0.05)。结论MMP2、MMP9和TIMP1参与了心室重构,阿托伐他汀治疗心衰是有效的。
Objective To investigate the change of MMP2,MMP9,TIMP1’s concentration in serum before and after heart failure and after give medicine.Methods Use the rabbit make animal model and then dispart for 3 groups,they are sham operation(SO) group,heart failure comparison(HC) group,heart failure treat with Atorvastatin(HA)group.HC group and HA group establish heart failure model.After 6 weeks of making model,we give HA group Atorvastatin for treatment,and then use ELISA to determine MMP2,MMP9,TIMP1’s concentration in serum of 3 groups before the opeartion,after 6 weeks of the opeartion and after 4 weeks of give medicine.Results Before opeartion the levels of several targets of 3 groups have no differences and statistics meanings(P>0.05).After 6 weeks of the opeartion,the levels of HC group and HA group all higher than SO group,they have differences and statistics meanings(P<0.05).After 4 weeks of give medicine,the level of 3 tragets of HA group is evidencely lower than HC group(P<0.05).Conclusions MMP2,MMP9 and TIMP1 attend ventricle remodeling,and it is effective that treat heart failure with Atorvastatin.
出处
《医学检验与临床》
2008年第4期29-31,共3页
Medical Laboratory Science and Clinics
