摘要
现阶段随机临床试验结果表明,惟一能改善急性缺血性卒中患者结局的是超早期(3 h内)采取标准化组织型纤溶酶原激活剂(t-PA)静脉溶栓治疗,但对最佳溶栓治疗策略来说仍有许多困难。利用影像学筛选3 h后静脉/动脉溶栓的急性卒中患者,是改善风险/效益比率、增加溶栓治疗获益的患者数量的新策略。
Evidence from randomized clinical trials indicates that systemic administration of tissue plasminogen activator (tPA) is a highly effective treatment for acute ischemic stroke,provided that treatment is administered within the first 3 h after stroke onset.There are still a number of burdens and failures in the optimal accomplishment of thromholytic treatment.However,important advances in clinical investigations suggest that new aims and hopes will be achieved in the near future.The use of neuroimaging for selecting acute stroke patients forⅣor IA thrombolysis after 3 h is promising strategy that may improve the risk/benefit ratio and increase the number of patients who will benefit from thromholytic therapy.
出处
《中国卒中杂志》
2006年第6期443-448,共6页
Chinese Journal of Stroke
基金
受"十五"国家科技攻关计划资助(课题编号:2004BA714B06-2)
关键词
急性缺血性卒中
溶栓
神经影像
临床研究
Acute ischemic stroke
Thrombolysis
Neuroimaging
Clinical study
