摘要
目的探讨血尿酸水平与冠心病的关系。方法选择129例冠状动脉造影病例,分为冠心病组100例和非冠心病组29例;冠心病组又分为单支病变组34例、双支病变组35例和三支病变组31例。两组均常规空腹采集静脉血测定血尿酸(SUA)水平,分析各组血尿酸水平与冠状动脉病变的相关性。结果冠心病组血尿酸水平(337.27±88.04)μmol/L明显高于非冠心病组(284.93±59.48)μmol/L(P<0.01)。单支病变亚组、双支病变亚组和三支病变亚组SUA水平呈递增趋势,分别为(323.00±80.30)μmol/L、(337.87±95.77)μmol/L和(352.15±80.04)μmol/L,但三者之间的差异无统计学意义(P>0.05),多元逐步回归结果显示SUA、纤维蛋白元、空腹血糖、高密度脂蛋白、低密度脂蛋白与冠状动脉病变评分独立相关(P值均<0.05)。结论血尿酸升高是冠心病发病的相关危险因素。
Objective To investigate the correlation between serum uric acid(SUA)and coronary heart disease(CHD). Methods Fasting venous blood samples were collected form 129 patients undergoing coronary angiography(CAG),100 being diagnosed as with CHD and 29 without CHD.The CHD group was re-divided into three subgroups:single-branch,double-branch.and three- branch subgroups according to the scope of pathological changes.The concentrations of SUA,fibrinogen(FIB),fasting plasma glucose(GLU),high-density lipoprotein(HDL),and low-density lipoprotein(LDL)were measured.Stepwise multiple regression analysis was made to investigate the association of CHD with SUA,FIB,fasting plasma glucose,HDL,and LDL. Results Results The SUA level in CHD group Was(337.27±88.04)μmol/L,significantly higher than that of the non-CHD group(284.93±59.48)μmol/L,P<0.01.There Was a trend of increase of SUA level in the single-branch subgroup,double-branch subgroup and three-branch subgroup,i.e.(323.00±80.30)μmol/L,(337.87±95.77)μmol/L and(352.15±80.04)μmol/L respectively,however,there were not significant differences in the SUA level among the 3 subgroups(all P>0.05). Stepwise multiple regression analysis showed that SUA,FIB,fasting plasma GLU,HDL,and LDL were independently associated with CHD severity (all P<0.05). Conclusion The elevation of SUA level is a correlative risk factor for CHD.
出处
《中国急救复苏与灾害医学杂志》
2007年第1期17-19,23,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
冠心病
血尿酸
危险因素
相关性
Coronary heart disease
Sermn uric acid
Risk factor
Relativity
