摘要
目的 探讨活血化瘀方剂抗肝纤维化的作用机理。方法 用活血化瘀水煎剂灌胃治疗ＣＣｌ４所致肝纤维化模型大鼠，免疫组织化学法检测增殖细胞核抗原、α－平滑肌肌动蛋白的表达，观察活血化瘀方对肝星形细胞活化的影响。结果 与自然恢复组相比，活血化瘀方剂可抑制肝星形细胞α－平滑肌肌动蛋白的表达（Ｐ＜０．０１），而对增殖细胞核抗原的表达无明显作用。结论 活血化瘀方能够抑制肝星形细胞向肌成纤维细胞的转化过程，对细胞因子介导的细胞增殖影响较小。
Objective To investigate the mechanisns of motiva ting blood circulation and removing blood stasis decoction for anti-hepatic fib r osis.Methods The hepatic fibrosis rats were fed with motivating b lood circulation and removing blood stasis decoction,PCNA and α-SMA expression of liver tissue were observed by means of immunohistochemical technique Results Motivating blood circulation and removing blood stasis d ecoction inhibited α-SMA expression of HSC compared with the self-restore gro unp (P＜0.01)and had no effect on PCNA.Conclusions Motivating blood circulation and removing blood stasis decoction inhibited the transformation of HSC to MFB and had no effect on cells; proliferatoin media ted by cytokines.
出处
《解剖学报》
CAS
CSCD
北大核心
2000年第z1期115-117,147,共4页
Acta Anatomica Sinica
关键词
肝星状细胞
增殖细胞核抗原
Α-平滑肌肌动蛋白
中药
Hepatic stellate cells
Proliferating cell nuclear antigen
α-smooth muscle actin
Chinese herbs
