摘要
目的研究莫沙比利(MOS)对40%血容量丢失大鼠早期口服葡萄糖-电解质液(GES)时胃排空的影响。方法雄性SD大鼠随机分为GES组(假手术后口服GES)、H+GES组(失血后口服GES液)和H+GES/MOS组(失血后口服GES和莫沙比利)。用氯胺酮-速眠新Ⅱ肌肉注射复合麻醉后,行右侧颈动脉插管,按全身血容量的40%分两次间隔15min放血制作失血性休克模型。于失血后0.5、1.0h分两次给予2倍失血量的GES灌胃。莫沙比利(0.5mg.kg-1.w-1)溶于GES,于首次灌胃时给予。失血后4.0h腹主动脉取血处死动物,检测血浆胃动素(MTL)和一氧化氮(NO)水平,酚红法测定胃排空率。结果失血后4.0hGES组、H+GES组和H+GES/MOS组胃排空率分别为(92±13)%、(62±11)%和(80±11)%,3组间差别有统计学意义(P<0.05)。H+GES/MOS组胃动素水平显著高于H+GES组〔(104±11)pg/L和(73±14)pg/L〕,但低于GES组〔(132±24)pg/L,P<0.05〕。H+GES/MOS组NO水平显著低于H+GES组〔(83±13)μmol/L和(106±13)μmol/L〕,但高于GES组〔(54±7)μmol/L,P<0.05〕。结论莫沙比利能显著增加大鼠失血性休克时血浆胃动素水平,降低NO水平,促进胃对口服液体的排空,提高口服补液复苏的效果。
Objective To investigate the effects of mosapride on gastric emptying and plasma motilin in oral medication of glucose electrolyte solution(GES) in hemorrhagic rats.Methods SD rats were randomly divided into GES group(oral GES after sham operations),H+GES(oral GES after hemorrhage),and GES/MOS(oral GES and mosapride).About 40% of total blood volume was let from rat carotid arteries to establish models of hemorrhagic shock in all groups.GES were given GES lavage by doubling the blood loss at min 30,60,respec...
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第10期855-856,共2页
Chinese General Practice
基金
全军医学科研"十一五"专项课题(06Z055)
关键词
休克
出血性
补液疗法
促胃动素
胃排空
Shock
hemorrhagic
Fluid replacement therapy
Motilin
Gastric emptying
