摘要
目的:观察黄连解毒汤对肺炎衣原体(Cpn)感染后高胆固醇饮食兔血液流变学和动脉粥样硬化的影响。方法:造模前60只新西兰兔经采血检测CpnIgG均为阴性。随机选取8只兔作正常组,其余52只以含2.5 g.kg-1胆固醇的饲料喂养并接种Cpn。经检测血清CpnIgG阳性者随机分为4组:黄连解毒汤高、低剂量(3.34,1.67 g.kg-1.d-1)组、阳性药阿奇霉素(20 mg.kg-1.d-1)组和模型组(生理盐水),每组11只,灌胃给药6周;CpnIgG阴性者作高胆固醇组,不予药物干预。治疗结束后采血测定高、中、低全血黏度、血浆黏度和红细胞压积,并计算RBC聚集指数、变形指数和刚性指数;取主动脉弓近左颈总动脉分叉处血管,测定和计算最大血管内膜厚度(M IT)、动脉粥样硬化病变占管周百分比(PLC I)、动脉粥样硬化斑块面积指数(IPA)。结果:高胆固醇组和模型组血液流变学均显著紊乱,主动脉均有典型的动脉粥样硬化病理变化,后者最大M IT(23.65±8.19 vs 12.76±4.06)μm、动脉粥样硬化病变PLC I(41.08±12.51 vs 22.43±9.45)%、动脉粥样硬化斑块IPA(9.57±1.82 vs 2.84±0.25)%显著较前者高(均P<0.01);黄连解毒汤高、低剂量组、阿奇霉素组血液流变学紊乱和动脉粥样硬化病理变化与模型组比较显著改善,其中黄连汤高剂量组M IT(6.45±1.27 vs 23.65±8.19),(P<0.01),PLC I(22.39±6.74 vs41.08±12.51),(P<0.05);IPA(1.44±0.33 vs 9.57±1.82),(P<0.01)显著降低。结论:Cpn感染加重高胆固醇饮食兔血液流变学紊乱和动脉粥样硬化损害,黄连解毒汤可减轻Cpn感染所致高胆固醇饮食兔的血液流变学紊乱和动脉粥样硬化损害。
Objective: To study the influence of Chlamydia pneumonia(Cpn) infection on haemorheology and atherosclerosis and the intervention of Huanglian Jiedu decoction(HJT).Method: At the beginning of the experiment,all the sixty New-Zealand rabbits were token blood to test Cpn IgG and all the results were negative.Eight New-Zealand rabbits were randomized into normal group F,and all other rabbits were fed with forage containing 2.5 g·kg-1 cholesterol and infected with Cpn via nasophrynx for three times during 6 wee...
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第5期600-604,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30070938)
关键词
肺炎衣原体
感染
动脉粥样硬化
黄连解毒汤
血液流变学
Chlamydia pneumonia
infection
atherosclerosis
antidotal decoction of Coptis
haemorheology
