摘要
采用小鼠肉瘤(S180)移植性肿瘤模型,观察灵雷菌质乙酸乙酯部位、正丁醇部位、石油醚部位和水部位提取物的肿瘤抑制作用,并测定小鼠的胸腺指数及脾脏指数。结果表明所有的提取物都呈现出明显的抑瘤效果,抑瘤率均大于35%,其中部分正丁醇部位的抑瘤率达到了68.88%。抑瘤效果由弱至强的顺序为石油醚部位<水部位<乙酸乙酯部位<正丁醇部位,而胸腺指数与脾脏指数则显示只有乙酸乙酯部位组有较明显的免疫抑制效果。双向性固体发酵可降低雷公藤的毒性,尤其正丁醇部位和水部位的毒性可能较弱。
The transplanting tumor model of mice sarcoma S180 was used to observe the anti-tumor effect of fermentation substance on Tripterygium, such as ethyl acetate part, n-butyl alcohol part, petroleun ether part and water part, and the thymus index and spleen index of mice had been measured. The results showed that all extracts had a significant inhibitory effect on tumor. The tumor inhibitory rates were all above 35% and the n-butyl alcohol part reached 68.88%. The inhibitory effect on tu- mor from low to high ...
出处
《中国食用菌》
北大核心
2009年第1期45-46,52,共3页
Edible Fungi of China
基金
科技部国际合作项目(雷公藤固体发酵减毒持效的研究)
项目编号:2006DFA33060
江西省卫生厅中医药科研计划(G菌固体发酵雷公藤减毒持效作用的功能酶系研究)
项目编号:赣卫中字[2007]20号。
关键词
双向性固体发酵
雷公藤
灵雷菌质
提取物
抗肿瘤作用
Bi-directional solid fermentation
Triperygium wilfordii Hook.
Fermentation substance on Tripterygium
Extract
Anti-tumor effect
