摘要
CYP2B6是一个在药理和毒理学上均占有重要地位的代谢酶,参与约7%临床上常用药物代谢,其中包括一些治疗窗较窄的药物。CYP2B6具有高度基因多态性,在基因编码区和非编码存在许多单碱基突变。到目前为止,已发现并被命名的等位基因有CYP2B6*1～*29。本文主要对CYP2B6的基因多态性、种族差异及其在药物代谢上的功能意义等方面的研究进展进行综述。
CYP2B6 is an important cytochrome P450 enzymes and contributes to metabolism of about 7% of therapeutically usual drugs,including some with narrow therapeutic index.The human CYP2B6 gene is highly polymorphic,having many single nucleotide polymorphisms in promoters and coding regions.To date,at least 29 CYP2B6 alleles have been identified.This review summarizes recent advances in the study of CYP2B6 about gene polymorphism,the frequency of CYP2B6 alleles among different populations,and their clincal signifi...
出处
《中国临床药理学与治疗学》
CAS
CSCD
2008年第12期1434-1440,共7页
Chinese Journal of Clinical Pharmacology and Therapeutics
