摘要
目的:探讨实验性急性出血坏死性胰腺炎(AHNP)时肿瘤坏死因子(TNF-α)及淀粉酶(AMY)的表达和黄连、大黄、丹参对它们的影响。方法:实验鼠采用3.5%牛磺胆酸钠(1.0 ml/kg)逆行胆胰管注射制成 AHNP 模型。治疗组分别予以10%黄连、大黄、丹参溶液术前2 h(1 ml/100 g)灌胃,术后6 h 观察胰腺组织的损伤程度及检测血清 TNF-α、淀粉酶变化。结果:AHNP 后 TNF-α 1 h 升高,6 h 达高峰;与 AHNP 对照组比较,黄连组、大黄组、丹参组及联合组大鼠血清 TNF-α及淀粉酶值均显著降低(P<0.01),胰腺组织病理损害明显减轻。结论:黄连、大黄、丹参均能有效的降低 AHNP 时 TNF-α的水平,减轻胰腺损害程度,对AHNP 有一定的治疗作用。
Objective:To explore the changes of tumor necrosis factor α(TNF-α)and amylase in experimental acute hemorrhagic necrotic pancreatitis(AHNP)and the effects of Coptis chinensis,Rheum palmatum and Salvia mihiorrhiza on them.Methods:Model rats of AHNP were established by intrapancreatic duct injection of 3.5% sodium taurocholate(1.0ml/kg)and those in the treated groups were treated with 10% solution of Coptis,Rheum and Salvia separately 2 hrs before modeling through gastrogavage.Changes of serum level of TNF-α,...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2002年第S1期128-130,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
急性出血坏死性胰腺炎
肿瘤坏死因子-Α
淀粉酶
黄连
大黄
丹参
acute hemorrhagic necrotic pancreatitis
tumor necrosis factor α
amylase
Coptis chinensis
Rheum palmatum
Salvia miltiorrhiza
