摘要
目的 应用高分辨率超声观察原发性高血压患者颈动脉内膜中膜厚度(IMT)并探讨其血管内皮功能及两者的相关性。方法 对46例高血压患者测定其IMT及反应性充血时和舌下含服硝酸甘油后肱动脉内径的变化,并对其进行相关分析。结果 高血压患者IMT(1.02±0.07mm)与正常对照组(0.78±0.05mm)比明显增厚(P<0.001)。反应性充血时肱动脉内径的扩张程度为(2.78±2.70％),与正常对照组相比差异非常显著(P<O.001)。IMT与反应性充血时和舌下含服硝酸甘油后肱动脉内径变化呈显著负相关。结论 原发性高血压患者存在明显的血管内皮依赖性及非依赖性舒张功能的损伤,内皮功能紊乱引起血管重构、肥厚、斑块形成。因此,原发性高血压的内皮功能损伤促进了动脉硬化的产生并加速了其硬化进程。
Objective To probe into the correlation between the carotid intima-media thickness (IMT)and endothelial function in patients with essential hypertension by using high resolution ultrasound. Methods Measuring the IMT and the changes of brachial artery intery internal diameter under the rdactive hyperermia situation of sublingual nitroglycerin in 46 patients with essential hypertension and analysing their correlation. Results IMTC1. 02±0. 07mm)in essential hypertension was pachynsed significantly(P<0. 001)...
出处
《西藏医药》
2003年第3期11-13,共3页
Tibetan Medicine
关键词
原发性高血压
血管内皮功能
颈动脉内膜中膜厚度
Essential hypertension Endothelial function Carotid intma-media thickness High resolution ultrasound
