摘要
To assay the antiviral activities on HSV-1 and CVB3 in vitro of the polysaccharide from Eucheuma striatum, its antiviral mechanism was explored. Vero cells were infected by HSV-1 and CVB3, and they were cultured with serial dilutions of polysaccharide. The cells cytotoxicity of Polysaccharide was evaluated by the MTT method. The inhibitory effects were evaluated by the cytopathic effect (CPE). Its antiviral mechanism was researched by the method of giving samples in different time. The polysaccharide could inhibit the CPE of cells infected by HSV-1 and CVB3. It showed low cytotoxicity on vero cells. Its antiviral activities were better than those of acyclovir and ribavirin which were run in parallel as the positive control samples. The polysaccharide from Eucheuma striatum has potent antiviral activities. Its antiviral mechanism is that it can prevent the virus from absorbing to the cell surface.……
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第z1期126-127,共2页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China (No. 2002A3050503) and the Natural Science Foundation of Guangdong Province (Nos. 2001-10-010401, 2003-11-039213).
