摘要
目的探讨植物甾醇月见草油对高脂血症性脂肪肝的治疗作用及其作用机制。方法采用高脂饲料喂饲法复制大鼠高脂血症性脂肪肝模型,实验分为正常对照组、模型对照组、溶剂对照组、受试物组,以及东宝肝泰对照组。受试物组设低、中、高三个剂量水平,分别为1.0g/(kg.d),2.0g/(kg.d),6.0g/(kg.d)。以植物甾醇月见草油和东宝肝泰进行干预,然后测定各组大鼠血脂、肝脂含量。结果与模型组对照组比较,受试物高剂量组能明显降低大鼠血清胆固醇(TC)、甘油三酯(TG)和肝组织中的TC、TG及低密度脂蛋白(LDL-C)含量,受试物中剂量组能明显降低血清中的TC、TG、LDL-C含量。结论植物甾醇月见草油可明显降低血脂及肝脂含量,提示该受试物在对高脂血症性脂肪肝大鼠具有调节血脂作用的同时,对脂肪肝有治疗作用。
OBJECTIVE To explore the possible role of the combination of phytosterol and evening primrose oil in the treatment of fatty liver with hypertipidemia.METHODS We duplicated fatty liver in hyperlipidemia animal model with high fat feedingstuff,divided the SD rats into 1 normal control group,1 model group,1 vehicle group,3 test substances group and 1 DongBaoGanTai group randomly.The dose levels were 1.0g/(kg·d),2.0g/(kg·d),6.0g/(kg·d) for 3 test substances groups respectively.Each treatment group was intervene...
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2006年第S1期606-609,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
植物甾醇月见草油
高脂血症
脂肪肝
大鼠
phytosterol and evening primrose oil
hyperlipemia
fatty liver
rats
