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活性氧—适应性免疫应答的调节分子 被引量：5

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摘要 在免疫系统中,吞噬细胞是活性氧(ROS)的主要来源,淋巴细胞也能经线粒体和NADPH氧化酶途径生成活性氧。活性氧不仅参与固有免疫应答的抗感染防御过程,也参与适应性免疫应答,包括抗原提呈及淋巴细胞活化、增殖、分化和凋亡等各个环节。活性氧的具体效应与其存在的位置及其量的多少密切相关。过氧化氢可作为第二信使,参与胞内信号通路。本文综述近年来关于活性氧参与免疫应答的研究进展,旨在为氧化应激相关疾病的治疗提供新的思路。
作者 张秋玉 苏东辉 李宁丽
机构地区 上海交通大学医学院
出处 《现代免疫学》 CAS CSCD 北大核心 2008年第1期75-78,共4页 Current Immunology
基金 国家自然科学基金资助项目(30671945) 上海市科委重大资助项目(06JC14044)
关键词 活性氧 免疫调节 淋巴细胞 第二信使
分类号 R392.12 [医药卫生—免疫学]
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参考文献10

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同被引文献35

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  • 8佘妙容,郭坤元,牛新清,卢晓珣,涂三芳.氧化还原状态的改变控制手霉素诱导HL-60白血病细胞凋亡[J].中国药理学通报,2008,24(6):772-777. 被引量：7
  • 9李妍,康辉.Th1、Th2和Th17型细胞在类风湿性关节炎和系统性红斑狼疮中的活化特点[J].微生物学杂志,2008,28(5):98-101. 被引量：22
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现代免疫学
2008年 第1期

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