摘要
目的:探讨复方丹参注射液对兔急性心肌梗塞细胞凋亡的影响。方法:采取末端脱氧核苷酸转换酶介导的dUTP-生物素平移末端标记技术对兔实验性急性心肌梗塞时不同损伤区心肌细胞凋亡情况进行研究,同时观察外周血超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果:对照组(急性心肌梗塞后静滴生理盐水)、用药组(急性心肌梗塞后静滴复方丹参注射液)的梗死区和再灌注区(梗死区边缘)心肌细胞凋亡阳性细胞数与阳性率均高于假手术组(不结扎冠脉静滴生理盐水)(P<0.001),用药组再灌注区心肌细胞凋亡阳性细胞数与阳性率低于对照组(P<0.05)。血浆SOD活性,用药组高于对照组(P<0.05),两组均低于假手术组(P<0.001)。血清脂质过氧化物产物MDA含量,用药组低于对照组(P<0.05),两组均高于假手术组(P<0.01)。结论:复方丹参注射液可能通过减少血清MDA含量、提高血浆SOD活性来减少急性心肌梗塞时再灌注区的心肌细胞凋亡数。
Objective:To study the effect of compostite Radix Salviae Militiorrhizae injectiion on myocyte apoptosis in experimental acute myocardial infarction of rabbits. Methods: The models of acute myocardial infarction were made with rabbits. The method of terminal deoxynu-cleotidyl transferase mediated dUTP nick end labeling was used to explore myocardial cell apoptosis in different injury area of acute myocardial infarction. The activities of plasma superoxide dismurase and the contents of serum malonic aldehyde...
出处
《中药材》
CAS
CSCD
北大核心
2001年第7期502-504,共3页
Journal of Chinese Medicinal Materials
关键词
复方丹参注射液
急性心肌梗塞
细胞凋亡
Composite Radix Salviae Militiorrhizae injectiion
Acute myocardial infarction
Apoptosis
