摘要
目的 :检测胃癌病人术前血清中血管内皮生长因子 (VEGF)浓度 ,探讨其临床及病理意义。方法 :应用酶联免疫技术 (ELISA法 )检测 51例胃癌病人、9例慢性胃炎病人及 10例健康人血清中VEGF浓度。结果 :胃癌病人血清VEGF浓度高于慢性胃炎病人及健康对照组 (P <0 0 5) ,慢性胃炎病人与健康对照组血清VEGF浓度无显著性差异 (P <0 0 5)。血清VEGF浓度与胃癌浸润深度(P <0 0 5)、淋巴结转移 (P <0 0 1)、远处转移 (P <0 0 1)、肿瘤分期 (P <0 0 5)及肿瘤组织学分型 (P <0 0 5)、生长方式 (P <0 0 5)密切相关 ,与性别无关 (P <0 0 5)。结论 :血清VEGF浓度与胃癌侵袭和转移密切相关。
Objective:In this study,serum concentration of vascular endothelial growth factor(VEGF)was measured to detect its clinical significance in patients with gastric cancer,Methods;Enzyme linked immunosorbent assay(ELISA)were used to detect serum VEGF concentration in 51 cases of human gastric carcinoma,9 cases of chronic gastritis and 10 healthy controls.Results:Serum VEGF concentration was much higher(P<0.05)in gastric cancer patients than that of chronic gastritis and healtby controls,But compared with h...
出处
《大连医科大学学报》
CAS
2001年第2期94-96,共3页
Journal of Dalian Medical University
关键词
胃肿瘤
血管内皮生长因子
肿瘤转移
血清
stomach neoplasms
vascular endothelial growth factor（VEGF）
meoplasm metastasis
serum
