摘要
微小分子核糖核酸(MicroRNAs , miRNAs)是一类长约21-25nt 的非编码的内源性单链 RNA 分子,序列在物种间具有高度保守性,其主要通过与靶mRNA 的3'非翻译区的碱基形成完全或不完全配对,从而达到直接降解或抑制靶 mRNA,进而发挥沉默基因或调控的作用,而这一作用使其广泛参与了细胞的增殖、分化、凋亡及肿瘤的发生等过程。近来越来越多的研究表明,microRNAs在动脉粥样硬化(atherosclerosis,AS)的发生发展过程中也发挥了极其重要的作用。另外一些微小核糖核酸可能是动脉粥样硬化的诊断标志物或者治疗目靶。现就最近的研究阐述miRNAs与动脉粥样硬化发生过程的关系。
MicroRNAs is one kind of endogenous noncoding,single-stranded,evolution arily conserved RNAs of 21-25 nucleotides.MiRNAs that bind to 3'UTR of mRNA with imperfect complementarity block protein translation.In contrast,miRNAs that bind mRNA with perfect complementarity induce targeted mRNA cleavage.Therefore just forthis ef ect,microRNAs can act as an important regulator for cellproliferation,dif erentiation,apoptosis and the development of cancer.In addition,an increasing number of recent studies have shown that microRNAs may play important roles in atherosclerosis.This article summarizes the current studies related to the disease correlations and functional roles of miRNAs participating in atherosclerosis development process.
作者
杜映荣
李红娟
DU Ying-rong;LI Hong-juan(Kunming Third People's Hospital,Kunming Yunnan 650041,China)
