摘要
目的研究动脉瘤性蛛网膜下腔出血(aSAH)患者血清中可溶性细胞间黏附分-1(sICAM-1)含量动态变化规律,分析其与脑血管痉挛(CVS)发生的时项、程度的相关性。方法对40例动脉瘤性蛛网膜下腔出血患者(实验组)发病后1~3d(术前)、7~9d、11~13d血清中sICAM-1(用ELISA法进行检测)进行动态检测,用TCD检测大脑中动脉血流速度(VMCA )。结果动脉瘤性蛛网膜下腔出血患者血清中sICAM-1含量明显高于对照组,尤以发病后7~9d显著;患者脑血管痉挛程度越重,血清中sICAM-1含量越高。结论动脉瘤性蛛网膜下腔出血患者血清中的slCAM-1含量高低可以反映患者脑血管痉挛病情的严重程度,可以作为动脉瘤性蛛网膜下腔出血患者发病后脑血管痉挛病情判断、指导临床治疗及预后判断的有效指标。
Objective To study the relationship between the serum concentration of sICAM-1with subarachnoid hemorrhage(aSAH)and the change of symptom,analysis its and cerebral vasospasm(CVS)of items,the degree of correlation.Methods Dynamical changes of the serum concentration of sICAM-1 during dif er days were observed in 40 cases with aSAH,TCD was used to measure VMCA,and control group for the same period to our healthy adult physical examination of 20 cases.Results Al the indexes in 1~3 days,7~9 days,11~13 after aSAH were significantly dif erent ccmpared with those of the controls.The indexes of 7~9 days after aSAH were most significant;The higher the Hunt-Hess classification and grade of Fisher,the higher the serum content of sICAM-1;Degree of patients with cerebral vasospasm is heavier,the higher the serum content of sICAM-1.Conclusion This findings suggest that there be a positive correlation between the serum concentration of sICAM-1 and the change of symptom CVS.
作者
郑华平
唐景峰
黄永旺
杨保华
王博
ZHENG Hua-ping;TANG Jing-feng;HUANG Yong-wang;YANG Bao-hua;WANG Bo(Guilin Medical College,Guilin 541000,Guangxi,China;Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi,China)
基金
广西卫生厅自筹经费课题(Z2007223).
