摘要
目的探讨益生菌联合肠内营养支持对重症急性胰腺炎患者免疫功能及炎症反应的影响.方法选取2020年5月—2022年2月本院收治的64例重症急性胰腺炎患者为研究对象,以随机数表法分为两组.对照组(n=32)采用肠内营养支持,观察组(n=32)采用益生菌联合肠内营养支持,均连续治疗1周.比较两组患者的临床疗效、免疫球蛋白水平、血清炎症因子水平及不良反应发生情况.结果观察组的治疗总有效率为93.75%,高于对照组的71.88%,差异有统计学意义(P<0.05).观察组治疗后的免疫球蛋白A、免疫球蛋白G、免疫球蛋白M水平分别为(2.73±0.42)g/L、(13.14±1.26)g/L、(1.84±0.35)g/L,均高于对照组的(2.54±0.31)g/L、(9.54±1.13)g/L、(1.15±0.27)g/L,组间差异有统计学意义(P<0.05).观察组治疗后的白细胞介素-6、肿瘤坏死因子-α、C反应蛋白水平分别为(11.13±2.04)ng/mL、(10.26±2.08)ng/mL、(15.13±2.01)ng/mL,均低于对照组的(18.24±2.12)ng/mL、(30.27±2.11)ng/mL、(54.68±5.21)ng/mL,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论采用益生菌结合肠内营养支持治疗重症急性胰腺炎患者的效果显著,可提高其机体免疫能力,降低炎性因子水平,且安全性较高.
Objective To investigate the effects of probiotics combined with enteral nutrition support on immune function and inflammatory response in patients with severe acute pancreatitis.Methods 64 patients with severe acute pancreatitis admitted to our hospital from May 2020 to February 2022 were selected and were divided into two groups by random number table method.The control group(n=32)received enteral nutrition support,and the observation group(n=32)received probiotics combined with enteral nutrition support.Both groups received continuous treatment for 1 week.The clinical efficacy,immunoglobulin levels,serum inflammatory factor levels and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.75%,which was higher than 71.88%of the control group,and the difference was statistically significant(P<0.05).The levels of immunoglobulin A,immunoglobulin G and immunoglobulin M after treatment in the observation group were(2.73±0.42)g/L,(13.14±1.26)g/L and(1.84±0.35)g/L,respectively,which were higher than(2.54±0.31)g/L,(9.54±1.13)g/L and(1.15±0.27)g/L in the control group,and the differences between the groups were statistically significant(P<0.05).The levels of interleukin-6,tumor necrosis factor-αand C-reactive protein after treatment in the observation group were(11.13±2.04)ng/mL,(10.26±2.08)ng/mL and(15.13±2.01)ng/mL,respectively,which were lower than(18.24±2.12)ng/mL,(30.27±2.11)ng/mL and(54.68±5.21)ng/mL in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Probiotics combined with enteral nutrition in the treatment of patients with severe acute pancreatitis have significant effects,can improve the immune capacity of the body,reduce the level of inflammatory factors,and high safety.
作者
赵英培
李岩岩
ZHAO Yingpei;LI Yanyan(Department of Clinical Nutrition,Liaocheng People's Hospital,Liaocheng Shandong,252500,China)
出处
《反射疗法与康复医学》
2023年第3期102-105,共4页
Reflexology And Rehabilitation Medicine
关键词
重症急性胰腺炎
益生菌
肠内营养支持
临床疗效
免疫功能
炎症反应
Severe acute pancreatitis
Probiotics
Enteral nutrition support
Clinical efficacy
Immune function
Inflammatory response
