摘要
目的分析丙种球蛋白与阿奇霉素序贯疗法联合治疗儿童重症肺炎支原体肺炎(SMPP)的效果.方法选取2021年1月—2023年10月该院收治的80例SMPP患儿为研究对象,按照随机数字表法将其分为对照组与研究组,每组40例.对照组采用阿奇霉素序贯疗法治疗,研究组在对照组基础上联合丙种球蛋白治疗.比较两组的疗效、症状与体征消退时间、C反应蛋白(CRP)与肿瘤坏死因子-α(TNF-α)水平,及不良反应发生情况.结果研究组治疗总有效率为95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05).研究组退热、肺部湿啰音消失、咳嗽消失时间均短于对照组,组间差异有统计学意义(P<0.05).治疗后,研究组TNF-α、CRP水平均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论丙种球蛋白与阿奇霉素序贯疗法联合治疗儿童SMPP的效果确切,能够促进患儿症状与体征快速消退,抑制机体炎症反应,具有临床应用价值.
Objective Analyze the efficacy of gamma globulin and sequential therapy with azithromycin in the treatment of severe mycoplasma pneumoniae pneumonia(SMPP)in children.Methods 80 children with SMPP admitted to the hospital from January 2021 to October 2023 were selected as the research subjects,divided them into a control group and a research group using a random number table method,with 40 cases in each group.The control group received sequential therapy with azithromycin,and the research group combined with gamma globulin therapy on the basis of the control group.The efficacy,time for symptom and sign resolution,C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)level and adverse reactions were compared between the two groups.Results The total effective rate of the research group was 95.00%,which was higher than 77.50%of the control group,the difference was statistically significant(P<0.05).The time of fever relief,disappearance of lung moist rales,and disappearance of cough in the research group were shorter than those in the control group,the differences between two groups was statistically significant(P<0.05).After treatment,the TNF-αand the CRP levels in the research group were lower than those in the control group,the differences between two groups were statistically significant(P<0.05).Comparison of incidence rates of adverse reactions between two groups,the difference was not statistically significant(P>0.05).Conclusion The combination of gamma globulin and sequential therapy with azithromycin has a definite effect on the treatment of childhood SMPP,which can promote the rapid resolution of symptoms and signs in children,inhibit the body's inflammatory response,and has clinical application value.
作者
田小红
TIAN Xiaohong(Department of Pediatrics,Shanghe County People's Hospital,Jinan Shandong,251600,China)
出处
《反射疗法与康复医学》
2024年第3期170-173,共4页
Reflexology And Rehabilitation Medicine
关键词
重症肺炎支原体肺炎
丙种球蛋白
阿奇霉素序贯疗法
儿童
Severe mycoplasma pneumoniae pneumoniu
Gamma globulin
Sequential therapy with azithromycin
Children
