摘要
目的:探讨初诊溃疡性结肠炎(UC)患者中性粒细胞与淋巴细胞比值(NLR)和血小板计数(PLT)的变化及其临床意义。方法:选择2020年3月至2022年3月我院收治的80例初诊UC患者作为研究组,并根据Truelove-Witts标准进一步分为轻度UC组(36例)、中度UC组(25例)、重度UC组(19例);同时选择同期80名健康志愿者作为对照组。比较各组UC患者NLR和PLT,分析NLR、PLT与UC严重程度的相关性,并应用ROC曲线分析NLR、PLT及两者联合判断UC病情的价值。结果:研究组患者总体NLR、PLT水平显著高于对照组,P<0.05。轻度、中度、重度UC组患者NLR均高于对照组,且各组间亦有统计学意义,P<0.05。中度、重度UC组患者PLT明显高于对照组,P<0.05;轻度UC组患者PLT与对照组比较无明显差异,P>0.05;重度UC组患者PLT明显高于轻度和中度UC组,P<0.05。Spearman相关性分析显示,NLR、PLT与UC严重程度均呈正相关(P<0.05)。ROC曲线分析显示,NLR、PLT单独及两者联合判断UC病情,曲线下面积(AUC)分别为0.70(0.63~0.76)、0.78(0.73~0.85)和0.83(0.77~0.88)。NLR、PLT联合判断UC病情优于单一指标,单一指标NLR优于PLT,P<0.05。结论:初诊UC患者NLR、PLT明显高于健康志愿者,且NLR、PLT水平与UC严重程度呈正相关,两者联合检测可用于初步评估UC病情。
Objective To investigate the changes of neutrophil-to-lymphocyto ratio(NLR)and platelet(PLT)in the initially diagnosed patients with ulcerative colitis(UC),and their clincial significance.Methods Enrolled the 80patients who were initially diagnosed as UC and treated in authors'hospital(2020-03-2022-03)into this study,then,according to Truelove-Witts standard divided them into mild UC group(36cases),moderate UC group(25cases),and severe UC group(19cases),at the same time,another 80 healthy volunteers as control group;then,compared the NLR and PLT of all groups'patients,further analysed the relativity of UC severity to NLR and PLT,as well as by using ROC curve for analysing the value of alone NLR or PLT,or combined NLR and PLT in judging UC condition.Results In three patients groups,their whole NLR and PLT level were all significantly higher than that of control group(P<0.05);in NLR level mild,moderate,and severe groups were higher than that of control group,also,between the three groups there was statistical difference(P<0.05);PLT of moderate and severe group's patients were significantly higher than that of control group(P<0.05),but there was no significant difference between the mild group and the control group(P>0.05);PLT of severe group's patients was significantly higher that of mild and moderate groups(P<0.05).Spearman relativity analysis showed NLR and PLT were positively related to the severity of UC(P<0.05).ROC analysis showed in judging UC condition by using alone NLR or PLT,or combined NRL and PLT,the AUC were respectively 0.70(0.63-0.76),or 0.78(0.73-0.85),or 0.83(0.77-0.88),thus combined detection's results were superior single detection's one,and NLR's results were superior to PLT's one(P<0.05).Conclusion The NLR and PLT results of patients initially diagnosed as UC are significantly higher than health volunteers'one,the NLR and levels of combined detection of NLR and PLT could be used in primarily evaluating UC condition.
作者
范婧婧
陈众
谷军星
FAN Jing-jing;CHEN Zhong;GU Jun-xing(Dept.of Medical Laboratory,Luoyang City's Hospital of TCM,Luoyang,Henan 471000)
出处
《中国肛肠病杂志》
2023年第2期25-27,共3页
Chinese Journal of Coloproctology
