摘要
目的:探讨食管癌体素内不相干运动(IVIM)多参数值与病理免疫组化指标血管内皮生长因子(VEGF)和微血管密度(MVD)的关系。方法:搜集36例食管癌患者,术前均由胃镜证实并且行3.0T MR食管癌常规序列和IVIM序列扫描,病理标本染色后获取VEGF及MVD,同时采用Spearman秩相关分析IVIM各参数值与免疫组化指标VEGF和MVD的相关性。结果:食管癌IVIM参数值ADC、D、D*及f值分别为(1.562±0.379)×10-3、(0.942±0.285)×10-3、(20.394±9.686)×10-3mm2/s和(0.505±0.109),VEGF和MVD测量值分别为(5.556±0.695)和(37.389±22.360)。其中D*值与VEGF呈正相关(r=0.335,P<0.05),ADC值、D值及f值与VEGF无相关性(P>0.05)。D*值及f值与MVD呈正相关(r=0.374,P<0.05;r=0.387,P<0.05),ADC值及D值与MVD无相关性(P>0.05)。结论:食管癌IVIM定量参数D*、f与VEGF和MVD呈正相关,体素内不相干运动成像定量参数D*及f可间接反映食管癌血管生成情况,可以作为食管癌术前无创性预测VEGF及MVD的影像学指标。
Objective:To investigate the correlation between the multi-parameter value of intravoxel incoherent motion(IVIM)and the expression of VEGF(vascular endothelial growth factor)and MVD(microvessel density)in esophageal carcinoma.Methods:Thirty-six patients with esophageal cancer were collected,all of whom were confirmed by gastroscopy preoperatively and underwent 3.0 T MR routine sequences and IVIM sequence scanning for esophageal cancer.The expressions of VEGF and MVD were detected by immunohistochemical staining,and the correlation between IVIM quantitative parameters and the expressions of VEGF and MVD was analyzed by Spearman rank correlation analysis.P<0.05 was the standard for statistical difference.Results:The IVIM parameter values of ADC,D,D*and f were(1.562±0.379)×10-3(0.942±0.285)×10-3,(20.394±9.686)×10-3mm2/s and(0.505±0.109),respectively.The measured values of VEGF and MVD were(5.556±0.695)and(37.389±22.360),respectively.D*value was positively correlated with VEGF(r=0.335,P<0.05).ADC value、D value and f value had no correlations with VEGF(P>0.05).D*value(r=0.374,P=0.024)and f value(r=0.387,P=0.020)was positively correlated with MVD.ADC value and D value had no correlations with MVD(P>0.05).Conclusion:D*and f were positively correlated with VEGF and MVD in esophageal cancer.Quantitative parameters D*and f of intravoxel incoherent motion can indirectly reflect angiogenesis of esophageal cancer,which can be used as imaging indexes for noninvasive prediction of VEGF and MVD before surgery.
作者
李泓享
李琳琳
刘月华
务森
崔云惠
刘圆圆
朱绍成
LI Hong-xiang;LI Lin-lin;LIU Yue-hua(Department of Radiology,Zhengzhou University People's Hospital,Henan Province People's Hospital,Zhengzhou 450003,China)
出处
《放射学实践》
北大核心
2020年第3期380-384,共5页
Radiologic Practice
基金
河南省医学科技攻关计划省部共建项目(SBGJ201868)
河南省科技攻关计划项目(182102311176).
关键词
食管肿瘤
体素内不相干运动
血管内皮生长因子
微血管密度
相关性分析
Esophageal neoplasm
Intravoxel incoherent motion
Vascular endothelial growth factor
Microvessel density
Correlation analysis
